The conformational properties of the Glc3Man unit suggest conformational biasing within the chaperone-assisted glycoprotein folding pathway.

The conformational properties of the Glc3Man unit suggest conformational biasing within the chaperone-assisted glycoprotein folding pathway.

A major puzzle is: are all glycoproteins routed through the ER calnexin pathway irrespective of whether this is required for their correct folding? Calnexin recognizes the terminal Glcalpha1-3Manalpha linkage, formed by trimming of the Glcalpha1-2Glcalpha1-3Glcalpha1-3Manalpha (Glc3Man) unit in Glc3...

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Bibliographic Details
Main Authors:	Mackeen, M, Almond, A, Deschamps, M, Cumpstey, I, Fairbanks, A, Tsang, C, Rudd, P, Butters, T, Dwek, R, Wormald, M
Format:	Journal article
Language:	English
Published:	2009

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