Chromophore-linked substrate (CLS405): Probing metallo-β-lactamase activity and inhibition

Serine- and metallo-β-lactamases present a threat to the clinical use of nearly all β-lactam antibiotics, including penicillins, cephalosporins, and carbapenems. Efforts to develop metallo-β-lactamase (MBL) inhibitors require suitable screening platforms to allow the rapid determination of β-lactama...

ver descrição completa

Detalhes bibliográficos
Principais autores: Makena, A, Van Berkel, S, Lejeune, C, Owens, R, Verma, A, Salimraj, R, Spencer, J, Brem, J, Schofield, C
Formato: Journal article
Idioma:English
Publicado em: 2013