A 4-dimensional representation of antennal lobe output based on an ensemble of characterized projection neurons.
A central problem facing studies of neural encoding in sensory systems is how to accurately quantify the extent of spatial and temporal responses. In this study, we take advantage of the relatively simple and stereotypic neural architecture found in invertebrates. We combine standard electrophysiolo...
| Huvudupphovsmän: | , , , |
|---|---|
| Materialtyp: | Journal article |
| Språk: | English |
| Publicerad: |
2009
|
| _version_ | 1826297020022784000 |
|---|---|
| author | Staudacher, E Huetteroth, W Schachtner, J Daly, K |
| author_facet | Staudacher, E Huetteroth, W Schachtner, J Daly, K |
| author_sort | Staudacher, E |
| collection | OXFORD |
| description | A central problem facing studies of neural encoding in sensory systems is how to accurately quantify the extent of spatial and temporal responses. In this study, we take advantage of the relatively simple and stereotypic neural architecture found in invertebrates. We combine standard electrophysiological techniques, recently developed population analysis techniques, and novel anatomical methods to form an innovative 4-dimensional view of odor output representations in the antennal lobe of the moth Manduca sexta. This novel approach allows quantification of olfactory responses of characterized neurons with spike time resolution. Additionally, arbitrary integration windows can be used for comparisons with other methods such as imaging. By assigning statistical significance to changes in neuronal firing, this method can visualize activity across the entire antennal lobe. The resulting 4-dimensional representation of antennal lobe output complements imaging and multi-unit experiments yet provides a more comprehensive and accurate view of glomerular activation patterns in spike time resolution. |
| first_indexed | 2024-03-07T04:25:14Z |
| format | Journal article |
| id | oxford-uuid:cc62fd29-a724-4e1c-88c9-9e7d9432a9a5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:25:14Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:cc62fd29-a724-4e1c-88c9-9e7d9432a9a52022-03-27T07:21:44ZA 4-dimensional representation of antennal lobe output based on an ensemble of characterized projection neurons.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:cc62fd29-a724-4e1c-88c9-9e7d9432a9a5EnglishSymplectic Elements at Oxford2009Staudacher, EHuetteroth, WSchachtner, JDaly, KA central problem facing studies of neural encoding in sensory systems is how to accurately quantify the extent of spatial and temporal responses. In this study, we take advantage of the relatively simple and stereotypic neural architecture found in invertebrates. We combine standard electrophysiological techniques, recently developed population analysis techniques, and novel anatomical methods to form an innovative 4-dimensional view of odor output representations in the antennal lobe of the moth Manduca sexta. This novel approach allows quantification of olfactory responses of characterized neurons with spike time resolution. Additionally, arbitrary integration windows can be used for comparisons with other methods such as imaging. By assigning statistical significance to changes in neuronal firing, this method can visualize activity across the entire antennal lobe. The resulting 4-dimensional representation of antennal lobe output complements imaging and multi-unit experiments yet provides a more comprehensive and accurate view of glomerular activation patterns in spike time resolution. |
| spellingShingle | Staudacher, E Huetteroth, W Schachtner, J Daly, K A 4-dimensional representation of antennal lobe output based on an ensemble of characterized projection neurons. |
| title | A 4-dimensional representation of antennal lobe output based on an ensemble of characterized projection neurons. |
| title_full | A 4-dimensional representation of antennal lobe output based on an ensemble of characterized projection neurons. |
| title_fullStr | A 4-dimensional representation of antennal lobe output based on an ensemble of characterized projection neurons. |
| title_full_unstemmed | A 4-dimensional representation of antennal lobe output based on an ensemble of characterized projection neurons. |
| title_short | A 4-dimensional representation of antennal lobe output based on an ensemble of characterized projection neurons. |
| title_sort | 4 dimensional representation of antennal lobe output based on an ensemble of characterized projection neurons |
| work_keys_str_mv | AT staudachere a4dimensionalrepresentationofantennallobeoutputbasedonanensembleofcharacterizedprojectionneurons AT huetterothw a4dimensionalrepresentationofantennallobeoutputbasedonanensembleofcharacterizedprojectionneurons AT schachtnerj a4dimensionalrepresentationofantennallobeoutputbasedonanensembleofcharacterizedprojectionneurons AT dalyk a4dimensionalrepresentationofantennallobeoutputbasedonanensembleofcharacterizedprojectionneurons AT staudachere 4dimensionalrepresentationofantennallobeoutputbasedonanensembleofcharacterizedprojectionneurons AT huetterothw 4dimensionalrepresentationofantennallobeoutputbasedonanensembleofcharacterizedprojectionneurons AT schachtnerj 4dimensionalrepresentationofantennallobeoutputbasedonanensembleofcharacterizedprojectionneurons AT dalyk 4dimensionalrepresentationofantennallobeoutputbasedonanensembleofcharacterizedprojectionneurons |