cGMP signals modulate cAMP levels in a compartment-specific manner to regulate catecholamine-dependent signaling in cardiac myocytes.

cGMP signals modulate cAMP levels in a compartment-specific manner to regulate catecholamine-dependent signaling in cardiac myocytes.

RATIONALE: cAMP and cGMP are intracellular second messengers involved in heart pathophysiology. cGMP can potentially affect cAMP signals via cGMP-regulated phosphodiesterases (PDEs). OBJECTIVE: To study the effect of cGMP signals on the local cAMP response to catecholamines in specific subcellular...

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Bibliographic Details
Main Authors: Stangherlin, A, Gesellchen, F, Zoccarato, A, Terrin, A, Fields, L, Berrera, M, Surdo, N, Craig, M, Smith, G, Hamilton, G, Zaccolo, M
Format: Journal article
Language:English
Published: 2011

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