Engineering carboxymethylproline synthases towards the biosynthetic productions of carbapenem antibiotics
<p>Mechanistic and biocatalytic studies of two carboxymethylproline synthases (CMPSs), CarB and ThnE, members of the crotonase superfamily of enzymes, both in isolation and in conjunction with the activity of the crotonyl-CoA carboxylase/reductase (Ccr) the malonyl-CoA synthetase (MatB) and th...
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| Format: | Thesis |
| Language: | English |
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2013
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