The impact of ethnicity on glucose regulation and the metabolic syndrome following gestational diabetes.
AIMS/HYPOTHESIS: We assessed the impact of ethnic origin on metabolism in women following gestational diabetes mellitus (GDM). MATERIALS AND METHODS: Glucose regulation and other features of the metabolic syndrome were studied at 20.0 (18.2-22.1) months (geometric mean [95% CI]) post-partum in women...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2006
|
| _version_ | 1797095296067436544 |
|---|---|
| author | Kousta, E Efstathiadou, Z Lawrence, N Jeffs, J Godsland, I Barrett, S Doré, C Penny, A Anyaoku, V Millauer, B Cela, E Robinson, S McCarthy, M Johnston, D |
| author_facet | Kousta, E Efstathiadou, Z Lawrence, N Jeffs, J Godsland, I Barrett, S Doré, C Penny, A Anyaoku, V Millauer, B Cela, E Robinson, S McCarthy, M Johnston, D |
| author_sort | Kousta, E |
| collection | OXFORD |
| description | AIMS/HYPOTHESIS: We assessed the impact of ethnic origin on metabolism in women following gestational diabetes mellitus (GDM). MATERIALS AND METHODS: Glucose regulation and other features of the metabolic syndrome were studied at 20.0 (18.2-22.1) months (geometric mean [95% CI]) post-partum in women with previous GDM (185 European, 103 Asian-Indian, 80 African-Caribbean). They were compared with the same features in 482 normal control subjects who had normal glucose regulation during and following pregnancy. RESULTS: Impaired glucose regulation or diabetes by WHO criteria were present in 37% of women with previous GDM (diabetes in 17%), especially in those of African-Caribbean and Asian-Indian origin (50 and 44%, respectively vs 28% in European, p=0.009). BMI, waist circumference, diastolic blood pressure, fasting triglyceride and insulin levels, and insulin resistance by homeostatic model assessment (HOMA), were increased following GDM (p<0.001 for all, vs control subjects). Where glucose regulation was normal following GDM, basal insulin secretion (by HOMA) was high (p<0.001 vs control subjects). Irrespective of glucose regulation in pregnancy, Asian-Indian origin was associated with high triglyceride and low HDL cholesterol levels, and African-Caribbean with increased waist circumference, blood pressure, and insulin levels, together with insulin resistance and low triglyceride concentrations. Nonetheless, the GDM-associated features were consistent within each ethnic group. The metabolic syndrome by International Diabetes Federation criteria was present in 37% of women with previous GDM, especially in non-Europeans (Asian-Indian 49%, African-Caribbean 43%, European 28%, p=0.001), and in 10% of controls. CONCLUSIONS/INTERPRETATION: Following GDM, abnormal glucose regulation and the metabolic syndrome are common, especially in non-European women, indicating a need for diabetes and cardiovascular disease prevention strategies. |
| first_indexed | 2024-03-07T04:25:51Z |
| format | Journal article |
| id | oxford-uuid:cc96dee9-ded9-48d4-98c1-92f733b0bb44 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:25:51Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:cc96dee9-ded9-48d4-98c1-92f733b0bb442022-03-27T07:23:02ZThe impact of ethnicity on glucose regulation and the metabolic syndrome following gestational diabetes.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:cc96dee9-ded9-48d4-98c1-92f733b0bb44EnglishSymplectic Elements at Oxford2006Kousta, EEfstathiadou, ZLawrence, NJeffs, JGodsland, IBarrett, SDoré, CPenny, AAnyaoku, VMillauer, BCela, ERobinson, SMcCarthy, MJohnston, DAIMS/HYPOTHESIS: We assessed the impact of ethnic origin on metabolism in women following gestational diabetes mellitus (GDM). MATERIALS AND METHODS: Glucose regulation and other features of the metabolic syndrome were studied at 20.0 (18.2-22.1) months (geometric mean [95% CI]) post-partum in women with previous GDM (185 European, 103 Asian-Indian, 80 African-Caribbean). They were compared with the same features in 482 normal control subjects who had normal glucose regulation during and following pregnancy. RESULTS: Impaired glucose regulation or diabetes by WHO criteria were present in 37% of women with previous GDM (diabetes in 17%), especially in those of African-Caribbean and Asian-Indian origin (50 and 44%, respectively vs 28% in European, p=0.009). BMI, waist circumference, diastolic blood pressure, fasting triglyceride and insulin levels, and insulin resistance by homeostatic model assessment (HOMA), were increased following GDM (p<0.001 for all, vs control subjects). Where glucose regulation was normal following GDM, basal insulin secretion (by HOMA) was high (p<0.001 vs control subjects). Irrespective of glucose regulation in pregnancy, Asian-Indian origin was associated with high triglyceride and low HDL cholesterol levels, and African-Caribbean with increased waist circumference, blood pressure, and insulin levels, together with insulin resistance and low triglyceride concentrations. Nonetheless, the GDM-associated features were consistent within each ethnic group. The metabolic syndrome by International Diabetes Federation criteria was present in 37% of women with previous GDM, especially in non-Europeans (Asian-Indian 49%, African-Caribbean 43%, European 28%, p=0.001), and in 10% of controls. CONCLUSIONS/INTERPRETATION: Following GDM, abnormal glucose regulation and the metabolic syndrome are common, especially in non-European women, indicating a need for diabetes and cardiovascular disease prevention strategies. |
| spellingShingle | Kousta, E Efstathiadou, Z Lawrence, N Jeffs, J Godsland, I Barrett, S Doré, C Penny, A Anyaoku, V Millauer, B Cela, E Robinson, S McCarthy, M Johnston, D The impact of ethnicity on glucose regulation and the metabolic syndrome following gestational diabetes. |
| title | The impact of ethnicity on glucose regulation and the metabolic syndrome following gestational diabetes. |
| title_full | The impact of ethnicity on glucose regulation and the metabolic syndrome following gestational diabetes. |
| title_fullStr | The impact of ethnicity on glucose regulation and the metabolic syndrome following gestational diabetes. |
| title_full_unstemmed | The impact of ethnicity on glucose regulation and the metabolic syndrome following gestational diabetes. |
| title_short | The impact of ethnicity on glucose regulation and the metabolic syndrome following gestational diabetes. |
| title_sort | impact of ethnicity on glucose regulation and the metabolic syndrome following gestational diabetes |
| work_keys_str_mv | AT koustae theimpactofethnicityonglucoseregulationandthemetabolicsyndromefollowinggestationaldiabetes AT efstathiadouz theimpactofethnicityonglucoseregulationandthemetabolicsyndromefollowinggestationaldiabetes AT lawrencen theimpactofethnicityonglucoseregulationandthemetabolicsyndromefollowinggestationaldiabetes AT jeffsj theimpactofethnicityonglucoseregulationandthemetabolicsyndromefollowinggestationaldiabetes AT godslandi theimpactofethnicityonglucoseregulationandthemetabolicsyndromefollowinggestationaldiabetes AT barretts theimpactofethnicityonglucoseregulationandthemetabolicsyndromefollowinggestationaldiabetes AT dorec theimpactofethnicityonglucoseregulationandthemetabolicsyndromefollowinggestationaldiabetes AT pennya theimpactofethnicityonglucoseregulationandthemetabolicsyndromefollowinggestationaldiabetes AT anyaokuv theimpactofethnicityonglucoseregulationandthemetabolicsyndromefollowinggestationaldiabetes AT millauerb theimpactofethnicityonglucoseregulationandthemetabolicsyndromefollowinggestationaldiabetes AT celae theimpactofethnicityonglucoseregulationandthemetabolicsyndromefollowinggestationaldiabetes AT robinsons theimpactofethnicityonglucoseregulationandthemetabolicsyndromefollowinggestationaldiabetes AT mccarthym theimpactofethnicityonglucoseregulationandthemetabolicsyndromefollowinggestationaldiabetes AT johnstond theimpactofethnicityonglucoseregulationandthemetabolicsyndromefollowinggestationaldiabetes AT koustae impactofethnicityonglucoseregulationandthemetabolicsyndromefollowinggestationaldiabetes AT efstathiadouz impactofethnicityonglucoseregulationandthemetabolicsyndromefollowinggestationaldiabetes AT lawrencen impactofethnicityonglucoseregulationandthemetabolicsyndromefollowinggestationaldiabetes AT jeffsj impactofethnicityonglucoseregulationandthemetabolicsyndromefollowinggestationaldiabetes AT godslandi impactofethnicityonglucoseregulationandthemetabolicsyndromefollowinggestationaldiabetes AT barretts impactofethnicityonglucoseregulationandthemetabolicsyndromefollowinggestationaldiabetes AT dorec impactofethnicityonglucoseregulationandthemetabolicsyndromefollowinggestationaldiabetes AT pennya impactofethnicityonglucoseregulationandthemetabolicsyndromefollowinggestationaldiabetes AT anyaokuv impactofethnicityonglucoseregulationandthemetabolicsyndromefollowinggestationaldiabetes AT millauerb impactofethnicityonglucoseregulationandthemetabolicsyndromefollowinggestationaldiabetes AT celae impactofethnicityonglucoseregulationandthemetabolicsyndromefollowinggestationaldiabetes AT robinsons impactofethnicityonglucoseregulationandthemetabolicsyndromefollowinggestationaldiabetes AT mccarthym impactofethnicityonglucoseregulationandthemetabolicsyndromefollowinggestationaldiabetes AT johnstond impactofethnicityonglucoseregulationandthemetabolicsyndromefollowinggestationaldiabetes |