Zfhx3 modulates retinal sensitivity and circadian responses to light

Zfhx3 modulates retinal sensitivity and circadian responses to light

Mutations in transcription factors often exhibit pleiotropic effects related to their complex expression patterns and multiple regulatory targets. One such mutation in the zinc finger homeobox 3 (ZFHX3) transcription factor, short circuit (Sci, Zfhx3Sci/+), is associated with significant circadian d...

Descripció completa

Dades bibliogràfiques
Autors principals:	Hughes, S, Edwards, JK, Wilcox, AG, Pothecary, CA, Barnard, AR, Joynson, R, Joynson, G, Hankins, MW, Peirson, SN, Banks, G, Nolan, PM
Format:	Journal article
Idioma:	English
Publicat:	Federation of American Societies for Experimental Biology 2021

Ítems similars

Zfhx3-mediated genetic ablation of the SCN abolishes light entrainable circadian activity while sparing food anticipatory activity
per: Ashleigh G. Wilcox, et al.
Publicat: (2021-10-01)

The regulatory factor ZFHX3 modifies circadian function in SCN via an AT motif-driven axis
per: Parsons, M, et al.
Publicat: (2015)

Circadian characterisation of the transcription factor Zfhx3 utilising a conditional mutagenesis approach
per: Wilcox, A
Publicat: (2019)

Reciprocal interactions between circadian clocks and aging.
per: Banks, G, et al.
Publicat: (2016)

Differential roles for cryptochromes in the mammalian retinal clock
per: Wong, J, et al.
Publicat: (2018)

Genetic background influences age-related decline in visual and nonvisual retinal responses, circadian rhythms, and sleep.
per: Banks, G, et al.
Publicat: (2015)

Nonuniform distribution and spectral tuning of photosensitive retinal ganglion cells of the mouse retina
per: Hughes, S, et al.
Publicat: (2013)

Nonuniform distribution and spectral tuning of photosensitive retinal ganglion cells of the mouse retina.
per: Hughes, S, et al.
Publicat: (2013)

Attenuated pupillary light responses and downregulation of opsin expression parallel decline in circadian disruption in two different mouse models of Huntington’s disease
per: Ouk, K, et al.
Publicat: (2016)

Functional characterisation of naturally occurring mutations in human melanopsin
per: Rodgers, J, et al.
Publicat: (2018)

Light, photoreceptors, and circadian clocks.
per: Foster, R, et al.
Publicat: (2007)

Metagenomic Analysis of the Gut Microbiome of the Common Black Slug Arion ater in Search of Novel Lignocellulose Degrading Enzymes
per: Ryan Joynson, et al.
Publicat: (2017-11-01)

Rapid Assessment of Sleep-Wake Behavior in Mice
per: Fisher, S, et al.
Publicat: (2012)

The Zfhx3-Mediated Axis Regulates Sleep and Interval Timing in Mice
per: Edoardo Balzani, et al.
Publicat: (2016-07-01)

Inhibitory effects of fluoxetine on photosensitive retinal ganglion cells
per: Hughes, S, et al.
Publicat: (2016)

An introduction to digital electronics and logic/
per: 423072 Joynson, R. H.
Publicat: (1981)

Better rugby for boys /
per: 330464 Joynson, David Cyril
Publicat: (1973)

The culture of scientific research [v1; ref status: indexed, http://f1000r.es/53j]
per: Catherine Joynson, et al.
Publicat: (2015-03-01)

Profound defects in pupillary responses to light in TRPM-channel null mice: a role for TRPM channels in non-image-forming photoreception.
per: Hughes, S, et al.
Publicat: (2012)

The functional characteristics of optogenetic gene therapy for vision restoration
per: Lindner, M, et al.
Publicat: (2020)

Long-term restoration of visual function in end-stage retinal degeneration using subretinal human melanopsin gene therapy
per: De Silva, SR, et al.
Publicat: (2017)

Behavioral abnormalities observed in Zfhx2-deficient mice.
per: Yuriko Komine, et al.
Publicat: (2012-01-01)

Telling the Time with a Broken Clock: Quantifying Circadian Disruption in Animal Models
per: Laurence A. Brown, et al.
Publicat: (2019-03-01)

Electroretinography of wild-type and Cry mutant mice reveals circadian tuning of photopic and mesopic retinal responses.
per: Cameron, M, et al.
Publicat: (2008)

Defining the impact of melanopsin missense polymorphisms using in vivo functional rescue
per: Rodgers, J, et al.
Publicat: (2018)

Dim light in the evening causes coordinated realignment of circadian rhythms, sleep, and short-term memory
per: Tam, SKE, et al.
Publicat: (2021)

Characterisation of light responses in the retina of mice lacking principle components of rod, cone and melanopsin phototransduction signalling pathways
per: Hughes, S, et al.
Publicat: (2016)

Circadian Photoentrainment in Mice and Humans
per: Russell G. Foster, et al.
Publicat: (2020-07-01)

Rapid assessment of sleep-wake behavior in mice.
per: Fisher, S, et al.
Publicat: (2012)

Filtration of short-wavelength light provides therapeutic benefit in Retinitis Pigmentosa caused by a common rhodopsin mutation.
per: Orlans, HO, et al.
Publicat: (2019)

Evaluation of the Digital Ventilated Cage® system for circadian phenotyping
per: Tir, S, et al.
Publicat: (2025)

Zfhx4 regulates endochondral ossification as the transcriptional platform of Osterix in mice
per: Eriko Nakamura, et al.
Publicat: (2021-11-01)

Sleep and circadian rhythm disruption in neuropsychiatric illness.
per: Jagannath, A, et al.
Publicat: (2013)

Sleep and circadian rhythm disruption in neuropsychiatric illness
per: Jagannath, A, et al.
Publicat: (2013)

The relationship between fasting-induced torpor, sleep and waking in laboratory mice
per: Huang, Y-G, et al.
Publicat: (2021)

Melanopsin phototransduction: Slowly emerging from the dark
per: Hughes, S, et al.
Publicat: (2012)

Expression of the candidate circadian photopigment melanopsin (Opn4) in the mouse retinal pigment epithelium.
per: Peirson, S, et al.
Publicat: (2004)

THE CHARACTERISTICS OF MIRNA BINDING SITES IN MRNA OF ZFHX3 GENE AND ITS ORTHOLOGS
per: A. М. Kondybayeva, et al.
Publicat: (2018-07-01)

Melanopsin regulates both sleep-promoting and arousal-promoting responses to light
per: Pilorz, V, et al.
Publicat: (2016)

Melanopsin regulates both sleep-promoting and arousal-promoting responses to light
per: Pilorz, V, et al.
Publicat: (2016)