Large-scale whole-exome sequencing association studies identify rare functional variants influencing serum urate levels

Large-scale whole-exome sequencing association studies identify rare functional variants influencing serum urate levels

Elevated serum urate levels can cause gout, an excruciating disease with suboptimal treatment. Previous GWAS identified common variants with modest effects on serum urate. Here we report large-scale whole-exome sequencing association studies of serum urate and kidney function among ≤19,517 European...

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Bibliographic Details
Main Authors: Tin, A, Li, Y, Brody, J, Nutile, T, Chu, A, Huffman, J, Yang, Q, Chen, M, Robinson-Cohen, C, Macé, A, Liu, J, Demirkan, A, Sorice, R, Sedaghat, S, Swen, M, Yu, B, Ghasemi, S, Teumer, A, Vollenweider, P, Ciullo, M, Li, M, Uitterlinden, A, Kraaij, R, Amin, N, Van Rooij, J, Kutalik, Z, Dehghan, A, McKnight, B, Van Duijn, C, Morrison, A, Psaty, B, Boerwinkle, E, Fox, C, Woodward, O, Köttgen, A
Format: Journal article
Language:English
Published: Nature Publishing Group 2018

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