New core promoter element in RNA polymerase II-dependent transcription: sequence-specific DNA binding by transcription factor IIB.
A sequence element located immediately upstream of the TATA element, and having the consensus sequence 5'-G/C-G/C-G/A-C-G-C-C-3', affects the ability of transcription factor IIB to enter transcription complexes and support transcription initiation. The sequence element is recognized direct...
| Main Authors: | , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
1998
|
| _version_ | 1826297091201171456 |
|---|---|
| author | Lagrange, T Kapanidis, A Tang, H Reinberg, D Ebright, R |
| author_facet | Lagrange, T Kapanidis, A Tang, H Reinberg, D Ebright, R |
| author_sort | Lagrange, T |
| collection | OXFORD |
| description | A sequence element located immediately upstream of the TATA element, and having the consensus sequence 5'-G/C-G/C-G/A-C-G-C-C-3', affects the ability of transcription factor IIB to enter transcription complexes and support transcription initiation. The sequence element is recognized directly by the transcription factor IIB. Recognition involves alpha-helices 4' and 5' of IIB, which comprise a helix-turn-helix DNA-binding motif. These observations establish that transcription initiation involves a fourth core promoter element, the IIB recognition element (BRE), in addition to the TATA element, the initiator element, and the downstream promoter element, and involves a second sequence-specific general transcription factor, IIB, in addition to transcription factor IID. |
| first_indexed | 2024-03-07T04:26:17Z |
| format | Journal article |
| id | oxford-uuid:ccbe664a-eaf8-4adc-8cb4-b64a700053d9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:26:17Z |
| publishDate | 1998 |
| record_format | dspace |
| spelling | oxford-uuid:ccbe664a-eaf8-4adc-8cb4-b64a700053d92022-03-27T07:23:58ZNew core promoter element in RNA polymerase II-dependent transcription: sequence-specific DNA binding by transcription factor IIB.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ccbe664a-eaf8-4adc-8cb4-b64a700053d9EnglishSymplectic Elements at Oxford1998Lagrange, TKapanidis, ATang, HReinberg, DEbright, RA sequence element located immediately upstream of the TATA element, and having the consensus sequence 5'-G/C-G/C-G/A-C-G-C-C-3', affects the ability of transcription factor IIB to enter transcription complexes and support transcription initiation. The sequence element is recognized directly by the transcription factor IIB. Recognition involves alpha-helices 4' and 5' of IIB, which comprise a helix-turn-helix DNA-binding motif. These observations establish that transcription initiation involves a fourth core promoter element, the IIB recognition element (BRE), in addition to the TATA element, the initiator element, and the downstream promoter element, and involves a second sequence-specific general transcription factor, IIB, in addition to transcription factor IID. |
| spellingShingle | Lagrange, T Kapanidis, A Tang, H Reinberg, D Ebright, R New core promoter element in RNA polymerase II-dependent transcription: sequence-specific DNA binding by transcription factor IIB. |
| title | New core promoter element in RNA polymerase II-dependent transcription: sequence-specific DNA binding by transcription factor IIB. |
| title_full | New core promoter element in RNA polymerase II-dependent transcription: sequence-specific DNA binding by transcription factor IIB. |
| title_fullStr | New core promoter element in RNA polymerase II-dependent transcription: sequence-specific DNA binding by transcription factor IIB. |
| title_full_unstemmed | New core promoter element in RNA polymerase II-dependent transcription: sequence-specific DNA binding by transcription factor IIB. |
| title_short | New core promoter element in RNA polymerase II-dependent transcription: sequence-specific DNA binding by transcription factor IIB. |
| title_sort | new core promoter element in rna polymerase ii dependent transcription sequence specific dna binding by transcription factor iib |
| work_keys_str_mv | AT lagranget newcorepromoterelementinrnapolymeraseiidependenttranscriptionsequencespecificdnabindingbytranscriptionfactoriib AT kapanidisa newcorepromoterelementinrnapolymeraseiidependenttranscriptionsequencespecificdnabindingbytranscriptionfactoriib AT tangh newcorepromoterelementinrnapolymeraseiidependenttranscriptionsequencespecificdnabindingbytranscriptionfactoriib AT reinbergd newcorepromoterelementinrnapolymeraseiidependenttranscriptionsequencespecificdnabindingbytranscriptionfactoriib AT ebrightr newcorepromoterelementinrnapolymeraseiidependenttranscriptionsequencespecificdnabindingbytranscriptionfactoriib |