2-Methoxyestradiol-3,17-O,O-bis-sulfamate (STX140) inhibits proliferation and invasion via senescence pathway induction in human BRAFi-resistant melanoma cells

The endogenous estradiol derivative 2-Methoxyestradiol (2-ME) has shown good and wide anticancer activity but suffers from poor oral bioavailability and extensive metabolic conjugation. However, its sulfamoylated derivative, 2-methoxyestradiol-3,17-O,O-bis-sulfamate (STX140), has superior potential...

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Váldodahkkit: Franco, YA, Oliveira de Moraes, Jr., M, Carvalho, LAC, Dohle, W, Oliveira da Silva, R, Noma, IHY, Lima, K, Potter, BVL, Machado-Neto, JA, Maria-Engler, SS
Materiálatiipa: Journal article
Giella:English
Almmustuhtton: MDPI 2023