Griseofulvin-induced aggregation of microtubule protein.
Griseofulvin (7-chloro-2',4,6-trimethoxy-6'-methylspiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione) induces aggregation of microtubule protein at 0 degrees C. This aggregate contains approx. 90% of the microtubule-associated proteins originally present in the microtubule prot...
| Main Authors: | , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
1977
|
| _version_ | 1797095350220095488 |
|---|---|
| author | Roobol, A Gull, K Pogson, C |
| author_facet | Roobol, A Gull, K Pogson, C |
| author_sort | Roobol, A |
| collection | OXFORD |
| description | Griseofulvin (7-chloro-2',4,6-trimethoxy-6'-methylspiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione) induces aggregation of microtubule protein at 0 degrees C. This aggregate contains approx. 90% of the microtubule-associated proteins originally present in the microtubule protein. The supernatant obtained after removal of the griseofulvin-induced aggregate does not form microtubules on warming at 37 degrees C. Addition of the griseofulvin-aggregated protein to this supernatant and warming to 37 degrees C gives rise to a limited amount of microtubule assembly. The possible involvement of griseofulvin-induced aggregation of microtubule protein at 0 degrees C in the inhibition by griseofulvin of microtubule assembly in vitro is discussed. |
| first_indexed | 2024-03-07T04:26:38Z |
| format | Journal article |
| id | oxford-uuid:ccddee0d-01d3-4f06-ae42-601d7c5adef9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:26:38Z |
| publishDate | 1977 |
| record_format | dspace |
| spelling | oxford-uuid:ccddee0d-01d3-4f06-ae42-601d7c5adef92022-03-27T07:24:47ZGriseofulvin-induced aggregation of microtubule protein.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ccddee0d-01d3-4f06-ae42-601d7c5adef9EnglishSymplectic Elements at Oxford1977Roobol, AGull, KPogson, CGriseofulvin (7-chloro-2',4,6-trimethoxy-6'-methylspiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione) induces aggregation of microtubule protein at 0 degrees C. This aggregate contains approx. 90% of the microtubule-associated proteins originally present in the microtubule protein. The supernatant obtained after removal of the griseofulvin-induced aggregate does not form microtubules on warming at 37 degrees C. Addition of the griseofulvin-aggregated protein to this supernatant and warming to 37 degrees C gives rise to a limited amount of microtubule assembly. The possible involvement of griseofulvin-induced aggregation of microtubule protein at 0 degrees C in the inhibition by griseofulvin of microtubule assembly in vitro is discussed. |
| spellingShingle | Roobol, A Gull, K Pogson, C Griseofulvin-induced aggregation of microtubule protein. |
| title | Griseofulvin-induced aggregation of microtubule protein. |
| title_full | Griseofulvin-induced aggregation of microtubule protein. |
| title_fullStr | Griseofulvin-induced aggregation of microtubule protein. |
| title_full_unstemmed | Griseofulvin-induced aggregation of microtubule protein. |
| title_short | Griseofulvin-induced aggregation of microtubule protein. |
| title_sort | griseofulvin induced aggregation of microtubule protein |
| work_keys_str_mv | AT roobola griseofulvininducedaggregationofmicrotubuleprotein AT gullk griseofulvininducedaggregationofmicrotubuleprotein AT pogsonc griseofulvininducedaggregationofmicrotubuleprotein |