Novel resorcin[4]arenes as potassium-selective ion-channel and transporter mimics.
A series of novel resorcin-[4]arenes with extended pi systems have been synthesised and developed as potassium-selective transporters. Resorcin[4]arenes that feature crown ether moieties function as efficient carriers of K+ across bulk liquid membranes showing enhanced selectivity over the other alk...
| Main Authors: | , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2001
|
| _version_ | 1797095356506308608 |
|---|---|
| author | Wright, A Matthews, SE Fischer, W Beer, P |
| author_facet | Wright, A Matthews, SE Fischer, W Beer, P |
| author_sort | Wright, A |
| collection | OXFORD |
| description | A series of novel resorcin-[4]arenes with extended pi systems have been synthesised and developed as potassium-selective transporters. Resorcin[4]arenes that feature crown ether moieties function as efficient carriers of K+ across bulk liquid membranes showing enhanced selectivity over the other alkali metal ions relative to a model system (benzo[15]crown-5). Incorporation of functionalities suitable for pore formation, in addition to an extra annulus of aromatic residues, gives molecules which have remarkable ion-channel-mimicking behaviour in a biological lipid bilayer with outstanding K+/Na+ selectivity. |
| first_indexed | 2024-03-07T04:26:44Z |
| format | Journal article |
| id | oxford-uuid:cce67496-93e0-415b-b7db-5842c2864ab7 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:26:44Z |
| publishDate | 2001 |
| record_format | dspace |
| spelling | oxford-uuid:cce67496-93e0-415b-b7db-5842c2864ab72022-03-27T07:24:58ZNovel resorcin[4]arenes as potassium-selective ion-channel and transporter mimics.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:cce67496-93e0-415b-b7db-5842c2864ab7EnglishSymplectic Elements at Oxford2001Wright, AMatthews, SEFischer, WBeer, PA series of novel resorcin-[4]arenes with extended pi systems have been synthesised and developed as potassium-selective transporters. Resorcin[4]arenes that feature crown ether moieties function as efficient carriers of K+ across bulk liquid membranes showing enhanced selectivity over the other alkali metal ions relative to a model system (benzo[15]crown-5). Incorporation of functionalities suitable for pore formation, in addition to an extra annulus of aromatic residues, gives molecules which have remarkable ion-channel-mimicking behaviour in a biological lipid bilayer with outstanding K+/Na+ selectivity. |
| spellingShingle | Wright, A Matthews, SE Fischer, W Beer, P Novel resorcin[4]arenes as potassium-selective ion-channel and transporter mimics. |
| title | Novel resorcin[4]arenes as potassium-selective ion-channel and transporter mimics. |
| title_full | Novel resorcin[4]arenes as potassium-selective ion-channel and transporter mimics. |
| title_fullStr | Novel resorcin[4]arenes as potassium-selective ion-channel and transporter mimics. |
| title_full_unstemmed | Novel resorcin[4]arenes as potassium-selective ion-channel and transporter mimics. |
| title_short | Novel resorcin[4]arenes as potassium-selective ion-channel and transporter mimics. |
| title_sort | novel resorcin 4 arenes as potassium selective ion channel and transporter mimics |
| work_keys_str_mv | AT wrighta novelresorcin4arenesaspotassiumselectiveionchannelandtransportermimics AT matthewsse novelresorcin4arenesaspotassiumselectiveionchannelandtransportermimics AT fischerw novelresorcin4arenesaspotassiumselectiveionchannelandtransportermimics AT beerp novelresorcin4arenesaspotassiumselectiveionchannelandtransportermimics |