A lower X-gate in TASK channels traps inhibitors within the vestibule

A lower X-gate in TASK channels traps inhibitors within the vestibule

TWIK-related acid-sensitive potassium (TASK) channels—members of the two pore domain potassium (K2P) channel family—are found in neurons1, cardiomyocytes2,3,4 and vascular smooth muscle cells5, where they are involved in the regulation of heart rate6, pulmonary artery tone5,7, sleep/wake cycles8 and...

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Main Authors: Rödstrom, K, Kiper, A, Zhang, W, Rinne, S, Pike, A, Goldstein, M, Conrad, L, Delbeck, M, Hahn, M, Meier, H, Platzk, M, Quigley, A, Speedman, D, Shrestha, L, Mukhopadhyay, S, Burgess-Brown, N, Tucker, S, Mueller, T, Decher, N, Carpenter, E
Format: Journal article
Language:English
Published: Nature Research 2020

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