Simultaneous in vivo assessment of cardiac and hepatic metabolism in the diabetic rat using hyperpolarized MRS

Simultaneous in vivo assessment of cardiac and hepatic metabolism in the diabetic rat using hyperpolarized MRS

Understanding and assessing diabetic metabolism is vital for monitoring disease progression and improving treatment of patients. In vivo assessments, using MRI and MRS, provide non-invasive and accurate measurements, and the development of hyperpolarized 13C spectroscopy in particular has been demon...

Full description

Bibliographic Details
Main Authors:	Le Page, L, Ball, D, Ball, V, Dodd, M, Miller, J, Heather, L, Tyler, D
Format:	Journal article
Published:	Wiley 2016

Similar Items

Assessment of real-time in vivo cardiac and hepatic glucose metabolism in the diabetic rat, using hyperpolarised C-13 pyruvate
by: Le Page, L, et al.
Published: (2013)

Hyperpolarized ketone body metabolism in the rat heart
by: Miller, J, et al.
Published: (2018)

In vivo alterations in cardiac metabolism and function in the spontaneously hypertensive rat heart.
by: Dodd, M, et al.
Published: (2012)

Assessing the optimal preparation strategy to minimize the variability of cardiac pyruvate dehydrogenase flux measurements with hyperpolarized MRS
by: Timm, KN, et al.
Published: (2018)

In vivo mouse cardiac hyperpolarized magnetic resonance spectroscopy.
by: Dodd, M, et al.
Published: (2013)

Hyperpolarized butyrate: a metabolic probe of short chain fatty acid metabolism in the heart.
by: Ball, DR, et al.
Published: (2014)

Assessing the effect of hypoxia on cardiac metabolism using Hyperpolarized 13C magnetic resonance spectroscopy
by: Le Page, L, et al.
Published: (2019)

Early detection of doxorubicin-induced cardiotoxicity in rats by its cardiac metabolic signature assessed with hyperpolarized MRI.
by: Timm, KN, et al.
Published: (2020)

Determination of cardiac metabolism in vivo with hyperpolarized carbon-13 magnetic resonance
by: Schroeder, M, et al.
Published: (2007)

Hyperpolarized 13 C and 31 P MRS detects differences in cardiac energetics, metabolism, and function in obesity, and responses following treatment
by: Lewis, AJM, et al.
Published: (2024)

Linking diabetic cardiovascular disease with non-alcoholic fatty liver disease through L-carnitine: A hyperpolarized MRS study
by: Savic, D, et al.
Published: (2019)

Application of hyperpolarized magnetic resonance in the study of cardiac metabolism
by: Tyler, D, et al.
Published: (2008)

In vivo cardiac 1H-MRS in the mouse.
by: Schneider, J, et al.
Published: (2004)

Hyperpolarized 13c magnetic resonance spectroscopy identifies changes to myocardial metabolic fluxes in a rat model of doxorubicin-induced cardiotoxicity
by: Timm, KN, et al.
Published: (2018)

Assessment of Metformin Induced Changes in Cardiac and Hepatic Redox State Using Hyperpolarized[1-13C]Pyruvate.
by: Lewis, A, et al.
Published: (2016)

In vivo carbon-13 dynamic MRS and MRSI of normal and fasted rat liver with hyperpolarized 13C-pyruvate.
by: Hu, S, et al.
Published: (2009)

L-Carnitine stimulates in vivo carbohydrate metabolism in the Type 1 diabetic heart as demonstrated by hyperpolarized MRI
by: Savic, D, et al.
Published: (2021)

Assessing the effect of anesthetic gas mixtures on hyperpolarized 13C pyruvate metabolism in the rat brain
by: Healicon, R, et al.
Published: (2022)

Fast Padé transform accelerated CSI for hyperpolarized MRS
by: Hansen, E, et al.
Published: (2016)

Probing hepatic metabolism of [2-13C]dihydroxyacetone in vivo with 1H-decoupled hyperpolarized 13C-MR
by: Marco-Rius, I, et al.
Published: (2020)

Non-invasive in vivo assessment of cardiac metabolism in the healthy and diabetic human heart using hyperpolarized 13C MRI
by: Rider, OJ, et al.
Published: (2020)

Non-invasive assessment of metformin induced changes in cardiac and hepatic redox state using hyperpolarized [1–13C] pyruvate
by: Lewis, A, et al.
Published: (2016)

Robust and high resolution hyperpolarized metabolic imaging of the rat heart at 7 t with 3d spectral-spatial EPI.
by: Miller, J, et al.
Published: (2015)

CHRONIC HYPOXIA CAUSES NO CHANGE IN CARDIAC PYRUVATE DEHYDROGENASE FLUX IN THE CONTROL OR DIABETIC RAT: AN IN VIVO STUDY
by: Le Page, L, et al.
Published: (2013)

Non-invasive immuno-metabolic cardiac inflammation imaging using hyperpolarized magnetic resonance
by: Lewis, A, et al.
Published: (2018)

Real-time assessment of Krebs cycle metabolism using hyperpolarized 13C magnetic resonance spectroscopy.
by: Schroeder, M, et al.
Published: (2009)

Simultaneous investigation of cardiac pyruvate dehydrogenase flux, Krebs cycle metabolism and pH, using hyperpolarized [1,2- C ]pyruvate in vivo
by: Chen, A, et al.
Published: (2012)

Use of Hyperpolarized Magnetic Resonance for Non-Invasive Observation of Metabolic Regulation
by: Schroeder, M, et al.
Published: (2008)

Validation of the in vivo assessment of pyruvate dehydrogenase activity using hyperpolarised 13C MRS.
by: Atherton, H, et al.
Published: (2011)

Clinical implications of cardiac hyperpolarized magnetic resonance imaging
by: Rider, O, et al.
Published: (2013)

Clinical implications of cardiac hyperpolarized magnetic resonance imaging
by: Rider, O, et al.
Published: (2013)

Hyperpolarized magnetic resonance shows that the antiischemic drug meldonium leads to increased flux through pyruvate dehydrogenase in vivo resulting in improved postischemic function in the diabetic heart
by: Savic, D, et al.
Published: (2021)

Simultaneous investigation of cardiac pyruvate dehydrogenase flux, Krebs cycle metabolism and pH, using hyperpolarized [1,2-(13)C2]pyruvate in vivo.
by: Chen, A, et al.
Published: (2012)

Reproducibility of human cardiac phosphorus MRS (31P‐MRS) at 7 T
by: Ellis, J, et al.
Published: (2019)

The effect of hyperpolarized tracer concentration on myocardial uptake and metabolism.
by: Schroeder, M, et al.
Published: (2009)

In vivo assessment of pyruvate dehydrogenase flux in the heart using hyperpolarized carbon-13 magnetic resonance.
by: Schroeder, M, et al.
Published: (2008)

IMPAIRED IN VIVO MITOCHONDRIAL KREBS CYCLE ACTIVITY FOLLOWING MYOCARDIAL INFARCTION ASSESSED USING HYPERPOLARIZED MAGNETIC RESONANCE SPECTROSCOPY
by: Dodd, M, et al.
Published: (2013)

A comparison of cardiac (31)P MRS at 1.5 and 3 T.
by: Tyler, D, et al.
Published: (2008)

A 3D hybrid-shot spiral sequence for hyperpolarized 13C imaging
by: Tyler, D, et al.
Published: (2020)

Impaired in vivo mitochondrial Krebs cycle activity after myocardial infarction assessed using hyperpolarized magnetic resonance spectroscopy.
by: Dodd, M, et al.
Published: (2014)