The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.

Variants in the FTO (fat mass and obesity associated) gene are associated with increased body mass index in humans. Here, we show by bioinformatics analysis that FTO shares sequence motifs with Fe(II)- and 2-oxoglutarate-dependent oxygenases. We find that recombinant murine Fto catalyzes the Fe(II)-...

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Hlavní autoři: Gerken, T, Girard, C, Tung, Y, Webby, C, Saudek, V, Hewitson, K, Yeo, G, McDonough, M, Cunliffe, S, McNeill, L, Galvanovskis, J, Rorsman, P, Robins, P, Prieur, X, Coll, A, Ma, M, Jovanovic, Z, Farooqi, I, Sedgwick, B, Barroso, I, Lindahl, T, Ponting, C, Ashcroft, F, O'Rahilly, S, Schofield, C
Médium: Journal article
Jazyk:English
Vydáno: 2007

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