Mapping gray and white matter volume abnormalities in early-onset psychosis: an ENIGMA multicenter voxel-based morphometry study
Introduction: Regional gray matter (GM) alterations have been reported in early-onset psychosis (EOP, onset before age 18), but previous studies have yielded conflicting results, likely due to small sample sizes and the different brain regions examined. In this study, we conducted a whole brain voxe...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Springer Nature [academic journals on nature.com]
2024
|
| _version_ | 1811140179498369024 |
|---|---|
| author | Si, S Bi, A Yu, Z See, C Kelly, S Ambrogi, S Arango, C Baeza, I Banaj, N Berk, M Castro-Fornieles, J Crespo-Facorro, B Crouse, JJ Díaz-Caneja, CM Fett, A Fortea, A Frangou, S Goldstein, BI Hickie, IB Janssen, J Kennedy, KG Krabbendam, L Kyriakopoulos, M MacIntosh, BJ McGuire, P James, A |
| author_facet | Si, S Bi, A Yu, Z See, C Kelly, S Ambrogi, S Arango, C Baeza, I Banaj, N Berk, M Castro-Fornieles, J Crespo-Facorro, B Crouse, JJ Díaz-Caneja, CM Fett, A Fortea, A Frangou, S Goldstein, BI Hickie, IB Janssen, J Kennedy, KG Krabbendam, L Kyriakopoulos, M MacIntosh, BJ McGuire, P James, A |
| author_sort | Si, S |
| collection | OXFORD |
| description | Introduction: Regional gray matter (GM) alterations have been reported in early-onset psychosis (EOP, onset before age 18), but previous studies have yielded conflicting results, likely due to small sample sizes and the different brain regions examined. In this study, we conducted a whole brain voxel-based morphometry (VBM) analysis in a large sample of individuals with EOP, using the newly developed ENIGMA-VBM tool. Methods: 15 independent cohorts from the ENIGMA-EOP working group participated in the study. The overall sample comprised T1-weighted MRI data from 482 individuals with EOP and 469 healthy controls. Each site performed the VBM analysis locally using the standardized ENIGMA-VBM tool. Statistical parametric T-maps were generated from each cohort and meta-analyzed to reveal voxel-wise differences between EOP and healthy controls as well as the individual-based association between GM volume and age of onset, chlorpromazine (CPZ) equivalent dose, and other clinical variables. Results: Compared with healthy controls, individuals with EOP showed widespread lower GM volume encompassing most of the cortex, with the most marked effect in the left median cingulate (Hedges’ g = 0.55, p = 0.001 corrected), as well as small clusters of lower white matter (WM), whereas no regional GM or WM volumes were higher in EOP. Lower GM volume in the cerebellum, thalamus and left inferior parietal gyrus was associated with older age of onset. Deficits in GM in the left inferior frontal gyrus, right insula, right precentral gyrus and right superior frontal gyrus were also associated with higher CPZ equivalent doses. Conclusion: EOP is associated with widespread reductions in cortical GM volume, while WM is affected to a smaller extent. GM volume alterations are associated with age of onset and CPZ equivalent dose but these effects are small compared to case-control differences. Mapping anatomical abnormalities in EOP may lead to a better understanding of the role of psychosis in brain development during childhood and adolescence. |
| first_indexed | 2024-09-25T04:17:52Z |
| format | Journal article |
| id | oxford-uuid:cd23dd04-dc69-4fda-b052-2749826061ea |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-09-25T04:17:52Z |
| publishDate | 2024 |
| publisher | Springer Nature [academic journals on nature.com] |
| record_format | dspace |
| spelling | oxford-uuid:cd23dd04-dc69-4fda-b052-2749826061ea2024-07-20T16:06:07ZMapping gray and white matter volume abnormalities in early-onset psychosis: an ENIGMA multicenter voxel-based morphometry studyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:cd23dd04-dc69-4fda-b052-2749826061eaEnglishJisc Publications RouterSpringer Nature [academic journals on nature.com]2024Si, SBi, AYu, ZSee, CKelly, SAmbrogi, SArango, CBaeza, IBanaj, NBerk, MCastro-Fornieles, JCrespo-Facorro, BCrouse, JJDíaz-Caneja, CMFett, AFortea, AFrangou, SGoldstein, BIHickie, IBJanssen, JKennedy, KGKrabbendam, LKyriakopoulos, MMacIntosh, BJMcGuire, PJames, AIntroduction: Regional gray matter (GM) alterations have been reported in early-onset psychosis (EOP, onset before age 18), but previous studies have yielded conflicting results, likely due to small sample sizes and the different brain regions examined. In this study, we conducted a whole brain voxel-based morphometry (VBM) analysis in a large sample of individuals with EOP, using the newly developed ENIGMA-VBM tool. Methods: 15 independent cohorts from the ENIGMA-EOP working group participated in the study. The overall sample comprised T1-weighted MRI data from 482 individuals with EOP and 469 healthy controls. Each site performed the VBM analysis locally using the standardized ENIGMA-VBM tool. Statistical parametric T-maps were generated from each cohort and meta-analyzed to reveal voxel-wise differences between EOP and healthy controls as well as the individual-based association between GM volume and age of onset, chlorpromazine (CPZ) equivalent dose, and other clinical variables. Results: Compared with healthy controls, individuals with EOP showed widespread lower GM volume encompassing most of the cortex, with the most marked effect in the left median cingulate (Hedges’ g = 0.55, p = 0.001 corrected), as well as small clusters of lower white matter (WM), whereas no regional GM or WM volumes were higher in EOP. Lower GM volume in the cerebellum, thalamus and left inferior parietal gyrus was associated with older age of onset. Deficits in GM in the left inferior frontal gyrus, right insula, right precentral gyrus and right superior frontal gyrus were also associated with higher CPZ equivalent doses. Conclusion: EOP is associated with widespread reductions in cortical GM volume, while WM is affected to a smaller extent. GM volume alterations are associated with age of onset and CPZ equivalent dose but these effects are small compared to case-control differences. Mapping anatomical abnormalities in EOP may lead to a better understanding of the role of psychosis in brain development during childhood and adolescence. |
| spellingShingle | Si, S Bi, A Yu, Z See, C Kelly, S Ambrogi, S Arango, C Baeza, I Banaj, N Berk, M Castro-Fornieles, J Crespo-Facorro, B Crouse, JJ Díaz-Caneja, CM Fett, A Fortea, A Frangou, S Goldstein, BI Hickie, IB Janssen, J Kennedy, KG Krabbendam, L Kyriakopoulos, M MacIntosh, BJ McGuire, P James, A Mapping gray and white matter volume abnormalities in early-onset psychosis: an ENIGMA multicenter voxel-based morphometry study |
| title | Mapping gray and white matter volume abnormalities in early-onset psychosis: an ENIGMA multicenter voxel-based morphometry study |
| title_full | Mapping gray and white matter volume abnormalities in early-onset psychosis: an ENIGMA multicenter voxel-based morphometry study |
| title_fullStr | Mapping gray and white matter volume abnormalities in early-onset psychosis: an ENIGMA multicenter voxel-based morphometry study |
| title_full_unstemmed | Mapping gray and white matter volume abnormalities in early-onset psychosis: an ENIGMA multicenter voxel-based morphometry study |
| title_short | Mapping gray and white matter volume abnormalities in early-onset psychosis: an ENIGMA multicenter voxel-based morphometry study |
| title_sort | mapping gray and white matter volume abnormalities in early onset psychosis an enigma multicenter voxel based morphometry study |
| work_keys_str_mv | AT sis mappinggrayandwhitemattervolumeabnormalitiesinearlyonsetpsychosisanenigmamulticentervoxelbasedmorphometrystudy AT bia mappinggrayandwhitemattervolumeabnormalitiesinearlyonsetpsychosisanenigmamulticentervoxelbasedmorphometrystudy AT yuz mappinggrayandwhitemattervolumeabnormalitiesinearlyonsetpsychosisanenigmamulticentervoxelbasedmorphometrystudy AT seec mappinggrayandwhitemattervolumeabnormalitiesinearlyonsetpsychosisanenigmamulticentervoxelbasedmorphometrystudy AT kellys mappinggrayandwhitemattervolumeabnormalitiesinearlyonsetpsychosisanenigmamulticentervoxelbasedmorphometrystudy AT ambrogis mappinggrayandwhitemattervolumeabnormalitiesinearlyonsetpsychosisanenigmamulticentervoxelbasedmorphometrystudy AT arangoc mappinggrayandwhitemattervolumeabnormalitiesinearlyonsetpsychosisanenigmamulticentervoxelbasedmorphometrystudy AT baezai mappinggrayandwhitemattervolumeabnormalitiesinearlyonsetpsychosisanenigmamulticentervoxelbasedmorphometrystudy AT banajn mappinggrayandwhitemattervolumeabnormalitiesinearlyonsetpsychosisanenigmamulticentervoxelbasedmorphometrystudy AT berkm mappinggrayandwhitemattervolumeabnormalitiesinearlyonsetpsychosisanenigmamulticentervoxelbasedmorphometrystudy AT castrofornielesj mappinggrayandwhitemattervolumeabnormalitiesinearlyonsetpsychosisanenigmamulticentervoxelbasedmorphometrystudy AT crespofacorrob mappinggrayandwhitemattervolumeabnormalitiesinearlyonsetpsychosisanenigmamulticentervoxelbasedmorphometrystudy AT crousejj mappinggrayandwhitemattervolumeabnormalitiesinearlyonsetpsychosisanenigmamulticentervoxelbasedmorphometrystudy AT diazcanejacm mappinggrayandwhitemattervolumeabnormalitiesinearlyonsetpsychosisanenigmamulticentervoxelbasedmorphometrystudy AT fetta mappinggrayandwhitemattervolumeabnormalitiesinearlyonsetpsychosisanenigmamulticentervoxelbasedmorphometrystudy AT forteaa mappinggrayandwhitemattervolumeabnormalitiesinearlyonsetpsychosisanenigmamulticentervoxelbasedmorphometrystudy AT frangous mappinggrayandwhitemattervolumeabnormalitiesinearlyonsetpsychosisanenigmamulticentervoxelbasedmorphometrystudy AT goldsteinbi mappinggrayandwhitemattervolumeabnormalitiesinearlyonsetpsychosisanenigmamulticentervoxelbasedmorphometrystudy AT hickieib mappinggrayandwhitemattervolumeabnormalitiesinearlyonsetpsychosisanenigmamulticentervoxelbasedmorphometrystudy AT janssenj mappinggrayandwhitemattervolumeabnormalitiesinearlyonsetpsychosisanenigmamulticentervoxelbasedmorphometrystudy AT kennedykg mappinggrayandwhitemattervolumeabnormalitiesinearlyonsetpsychosisanenigmamulticentervoxelbasedmorphometrystudy AT krabbendaml mappinggrayandwhitemattervolumeabnormalitiesinearlyonsetpsychosisanenigmamulticentervoxelbasedmorphometrystudy AT kyriakopoulosm mappinggrayandwhitemattervolumeabnormalitiesinearlyonsetpsychosisanenigmamulticentervoxelbasedmorphometrystudy AT macintoshbj mappinggrayandwhitemattervolumeabnormalitiesinearlyonsetpsychosisanenigmamulticentervoxelbasedmorphometrystudy AT mcguirep mappinggrayandwhitemattervolumeabnormalitiesinearlyonsetpsychosisanenigmamulticentervoxelbasedmorphometrystudy AT jamesa mappinggrayandwhitemattervolumeabnormalitiesinearlyonsetpsychosisanenigmamulticentervoxelbasedmorphometrystudy |