Substitution rates in the X- and Y-linked genes of the plants, Silene latifolia and S. dioica.
Theory predicts that selection should be less effective in the nonrecombining genes of Y-chromosomes, relative to the situation for genes on the other chromosomes, and this should lead to the accumulation of deleterious nonsynonymous substitutions. In addition, synonymous substitution rates may diff...
| Príomhchruthaitheoirí: | , |
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| Formáid: | Journal article |
| Teanga: | English |
| Foilsithe / Cruthaithe: |
2002
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| _version_ | 1826297168295624704 |
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| author | Filatov, D Charlesworth, D |
| author_facet | Filatov, D Charlesworth, D |
| author_sort | Filatov, D |
| collection | OXFORD |
| description | Theory predicts that selection should be less effective in the nonrecombining genes of Y-chromosomes, relative to the situation for genes on the other chromosomes, and this should lead to the accumulation of deleterious nonsynonymous substitutions. In addition, synonymous substitution rates may differ between X- and Y-linked genes because of the male-driven evolution effect and also because of actual differences in per-replication mutation rates between the sex chromosomes. Here, we report the first study of synonymous and nonsynonymous substitution rates on plant sex chromosomes. We sequenced two pairs of sex-linked genes, SlX1-SlY1 and SlX4-SlY4, from dioecious Silene latifolia and S. dioica, and their non-sex-linked homologues from nondioecious S. vulgaris and Lychnis flos-jovis, respectively. The rate of nonsynonymous substitutions in the SlY4 gene is significantly higher than that in the SlX4 gene. Silent substitution rates are also significantly higher in both Y-linked genes, compared with their X-linked homologues. The higher nonsynonymous substitution rate in the SlY4 gene is therefore likely to be caused by a mutation rate difference between the sex chromosomes. The difference in silent substitution rates between the SlX4 and SlY4 genes is too great to be explained solely by a higher per-generation mutation rate in males than females. It is thus probably caused by a difference in per-replication mutation rates between the sex chromosomes. This suggests that the local mutation rate can change in a relatively short evolutionary time. |
| first_indexed | 2024-03-07T04:27:26Z |
| format | Journal article |
| id | oxford-uuid:cd24193a-2ac1-45db-85ce-0adf02b6bdd5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:27:26Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:cd24193a-2ac1-45db-85ce-0adf02b6bdd52022-03-27T07:26:36ZSubstitution rates in the X- and Y-linked genes of the plants, Silene latifolia and S. dioica.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:cd24193a-2ac1-45db-85ce-0adf02b6bdd5EnglishSymplectic Elements at Oxford2002Filatov, DCharlesworth, DTheory predicts that selection should be less effective in the nonrecombining genes of Y-chromosomes, relative to the situation for genes on the other chromosomes, and this should lead to the accumulation of deleterious nonsynonymous substitutions. In addition, synonymous substitution rates may differ between X- and Y-linked genes because of the male-driven evolution effect and also because of actual differences in per-replication mutation rates between the sex chromosomes. Here, we report the first study of synonymous and nonsynonymous substitution rates on plant sex chromosomes. We sequenced two pairs of sex-linked genes, SlX1-SlY1 and SlX4-SlY4, from dioecious Silene latifolia and S. dioica, and their non-sex-linked homologues from nondioecious S. vulgaris and Lychnis flos-jovis, respectively. The rate of nonsynonymous substitutions in the SlY4 gene is significantly higher than that in the SlX4 gene. Silent substitution rates are also significantly higher in both Y-linked genes, compared with their X-linked homologues. The higher nonsynonymous substitution rate in the SlY4 gene is therefore likely to be caused by a mutation rate difference between the sex chromosomes. The difference in silent substitution rates between the SlX4 and SlY4 genes is too great to be explained solely by a higher per-generation mutation rate in males than females. It is thus probably caused by a difference in per-replication mutation rates between the sex chromosomes. This suggests that the local mutation rate can change in a relatively short evolutionary time. |
| spellingShingle | Filatov, D Charlesworth, D Substitution rates in the X- and Y-linked genes of the plants, Silene latifolia and S. dioica. |
| title | Substitution rates in the X- and Y-linked genes of the plants, Silene latifolia and S. dioica. |
| title_full | Substitution rates in the X- and Y-linked genes of the plants, Silene latifolia and S. dioica. |
| title_fullStr | Substitution rates in the X- and Y-linked genes of the plants, Silene latifolia and S. dioica. |
| title_full_unstemmed | Substitution rates in the X- and Y-linked genes of the plants, Silene latifolia and S. dioica. |
| title_short | Substitution rates in the X- and Y-linked genes of the plants, Silene latifolia and S. dioica. |
| title_sort | substitution rates in the x and y linked genes of the plants silene latifolia and s dioica |
| work_keys_str_mv | AT filatovd substitutionratesinthexandylinkedgenesoftheplantssilenelatifoliaandsdioica AT charlesworthd substitutionratesinthexandylinkedgenesoftheplantssilenelatifoliaandsdioica |