Derivation and application of molecular signatures to prostate cancer: Opportunities and challenges
Prostate cancer is a high-incidence cancer that requires improved patient stratification to ensure accurate predictions of risk and treatment response. Due to the significant contributions of transcription factors and epigenetic regulators to prostate cancer progression, there has been considerable...
| Main Authors: | , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
MDPI
2021
|
| _version_ | 1797095414496755712 |
|---|---|
| author | Doultsinos, D Mills, IG |
| author_facet | Doultsinos, D Mills, IG |
| author_sort | Doultsinos, D |
| collection | OXFORD |
| description | Prostate cancer is a high-incidence cancer that requires improved patient stratification to ensure accurate predictions of risk and treatment response. Due to the significant contributions of transcription factors and epigenetic regulators to prostate cancer progression, there has been considerable progress made in developing gene signatures that may achieve this. Some of these are aligned to activities of key drivers such as the androgen receptor, whilst others are more agnostic. In this review, we present an overview of these signatures, the strategies for their derivation, and future perspectives on their continued development and evolution. |
| first_indexed | 2024-03-07T04:27:30Z |
| format | Journal article |
| id | oxford-uuid:cd283cb2-61b5-402e-8413-4c3e5eb51db0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:27:30Z |
| publishDate | 2021 |
| publisher | MDPI |
| record_format | dspace |
| spelling | oxford-uuid:cd283cb2-61b5-402e-8413-4c3e5eb51db02022-03-27T07:26:47ZDerivation and application of molecular signatures to prostate cancer: Opportunities and challengesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:cd283cb2-61b5-402e-8413-4c3e5eb51db0EnglishSymplectic ElementsMDPI2021Doultsinos, DMills, IGProstate cancer is a high-incidence cancer that requires improved patient stratification to ensure accurate predictions of risk and treatment response. Due to the significant contributions of transcription factors and epigenetic regulators to prostate cancer progression, there has been considerable progress made in developing gene signatures that may achieve this. Some of these are aligned to activities of key drivers such as the androgen receptor, whilst others are more agnostic. In this review, we present an overview of these signatures, the strategies for their derivation, and future perspectives on their continued development and evolution. |
| spellingShingle | Doultsinos, D Mills, IG Derivation and application of molecular signatures to prostate cancer: Opportunities and challenges |
| title | Derivation and application of molecular signatures to prostate cancer: Opportunities and challenges |
| title_full | Derivation and application of molecular signatures to prostate cancer: Opportunities and challenges |
| title_fullStr | Derivation and application of molecular signatures to prostate cancer: Opportunities and challenges |
| title_full_unstemmed | Derivation and application of molecular signatures to prostate cancer: Opportunities and challenges |
| title_short | Derivation and application of molecular signatures to prostate cancer: Opportunities and challenges |
| title_sort | derivation and application of molecular signatures to prostate cancer opportunities and challenges |
| work_keys_str_mv | AT doultsinosd derivationandapplicationofmolecularsignaturestoprostatecanceropportunitiesandchallenges AT millsig derivationandapplicationofmolecularsignaturestoprostatecanceropportunitiesandchallenges |