The synthesis of (+/-)-heliotridane and (6S,7S)-dihydroxyheliotridane via sequential hydrogen atom abstraction and cyclisation
Treatment of N-(3-bromo-3-butenyl)pyrrolidine derivatives with tributyltin hydride and AIBN leads to hydrogen atom transfer of the intermediate vinyl radicals to give α-amino radicals which then cyclise stereoselectively yielding pyrrolizidines 1 and 13.
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1996
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| Summary: | Treatment of N-(3-bromo-3-butenyl)pyrrolidine derivatives with tributyltin hydride and AIBN leads to hydrogen atom transfer of the intermediate vinyl radicals to give α-amino radicals which then cyclise stereoselectively yielding pyrrolizidines 1 and 13. |
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