Of mice and men: is there a future for metformin in the treatment of hepatic steatosis?

Of mice and men: is there a future for metformin in the treatment of hepatic steatosis?

Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of liver diseases, of which the first stage is steatosis. It is one of the most common liver diseases in developed countries and there is a clear association between type 2 diabetes (T2DM) and NAFLD. It is estimated that 70% of people...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoirí:	Green, C, Marjot, T, Tomlinson, J, Hodson, L
Formáid:	Journal article
Teanga:	English
Foilsithe / Cruthaithe:	Wiley 2018

Míreanna comhchosúla

Sodium-glucose cotransporter 2 inhibition does not reduce hepatic steatosis in overweight, insulin-resistant patients without type 2 diabetes
de réir: Marjot, T, et al.
Foilsithe / Cruthaithe: (2019)

Metformin maintains intrahepatic triglyceride content through increased hepatic de novo lipogenesis
de réir: Green, CJ, et al.
Foilsithe / Cruthaithe: (2022)

Sodium‐glucose cotransporter 2 inhibition does not reduce hepatic steatosis in overweight, insulin‐resistant patients without type 2 diabetes
de réir: Thomas Marjot, et al.
Foilsithe / Cruthaithe: (2020-06-01)

Are oxidative stress mechanisms the common denominator in the progression from hepatic steatosis towards non-alcoholic steatohepatitis (NASH)?
de réir: Tariq, Z, et al.
Foilsithe / Cruthaithe: (2014)

Are oxidative stress mechanisms the common denominator in the progression from hepatic steatosis towards non-alcoholic steatohepatitis (NASH)?
de réir: Tariq, Z, et al.
Foilsithe / Cruthaithe: (2014)

Ginseng berry extract enhances metformin efficacy against obesity and hepatic steatosis in mice fed high-fat diet through increase of metformin uptake in liver
de réir: Hee-Sung Chae, et al.
Foilsithe / Cruthaithe: (2019-11-01)

Treatment with Lobeglitazone Attenuates Hepatic Steatosis in Diet-Induced Obese Mice
de réir: Sorim Choung, et al.
Foilsithe / Cruthaithe: (2018-01-01)

Metformin ameliorates hepatic steatosis and inflammation without altering adipose phenotype in diet-induced obesity.
de réir: Shih-Lung Woo, et al.
Foilsithe / Cruthaithe: (2014-01-01)

Quercitrin Ameliorates Hyperlipidemia and Hepatic Steatosis in Ovariectomized Mice
de réir: Haeng Jeon Hur, et al.
Foilsithe / Cruthaithe: (2020-10-01)

Comparison of Pioglitazone and Metformin Efficacy against Glucocorticoid Induced Atherosclerosis and Hepatic Steatosis in Insulin Resistant Rats
de réir: I M Nagendra Nayak, et al.
Foilsithe / Cruthaithe: (2017-07-01)

Metformin Ameliorates Hepatic Steatosis induced by olanzapine through inhibiting LXRα/PCSK9 pathway
de réir: Wenqiang Zhu, et al.
Foilsithe / Cruthaithe: (2022-04-01)

Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet*
de réir: Mary E. Rinella, et al.
Foilsithe / Cruthaithe: (2008-05-01)

Effects of bile acid sequestration on hepatic steatosis in obese mice
de réir: Nancy Solís, et al.
Foilsithe / Cruthaithe: (2014-01-01)

NAMPT overexpression alleviates alcohol-induced hepatic steatosis in mice.
de réir: Xiwen Xiong, et al.
Foilsithe / Cruthaithe: (2019-01-01)

Histologically proven hepatic steatosis associates with lower testosterone levels in men with obesity
de réir: Frederique Van de Velde, et al.
Foilsithe / Cruthaithe: (2020-01-01)

Non-alcoholic fatty liver disease in adults: Current concepts in etiology, outcomes and management
de réir: Marjot, T, et al.
Foilsithe / Cruthaithe: (2019)

Functional multispectral optoacoustic tomography imaging of hepatic steatosis development in mice
de réir: Shan Huang, et al.
Foilsithe / Cruthaithe: (2021-08-01)

Incidental Hepatic Steatosis
de réir: Lawrence S. Friedman, et al.
Foilsithe / Cruthaithe: (2023-01-01)

Genetic and hormonal control of hepatic steatosis in female and male mice1
de réir: Frode Norheim, et al.
Foilsithe / Cruthaithe: (2017-01-01)

Palmitoleate induces hepatic steatosis but suppresses liver inflammatory response in mice.
de réir: Xin Guo, et al.
Foilsithe / Cruthaithe: (2012-01-01)

Computed Tomography Measurement of Hepatic Steatosis: Prevalence of Hepatic Steatosis in a Canadian Population
de réir: Malcolm M. Wells, et al.
Foilsithe / Cruthaithe: (2016-01-01)

Exposure to low-dose perfluorooctanoic acid promotes hepatic steatosis and disrupts the hepatic transcriptome in mice
de réir: Brecht Attema, et al.
Foilsithe / Cruthaithe: (2022-12-01)

Chronic Treatment with Metformin Has No Disrupting Effect on the Hepatic Circadian Clock in Mice
de réir: Nazmul Hasan, et al.
Foilsithe / Cruthaithe: (2022-02-01)

Bilirubin deficiency renders mice susceptible to hepatic steatosis in the absence of insulin resistance
de réir: Weiyu Chen, et al.
Foilsithe / Cruthaithe: (2021-11-01)

TRIF Differentially Regulates Hepatic Steatosis and Inflammation/Fibrosis in MiceSummary
de réir: Ling Yang, et al.
Foilsithe / Cruthaithe: (2017-05-01)

Efficacy of Acetylshikonin in Preventing Obesity and Hepatic Steatosis in db/db Mice
de réir: Mei-Ling Su, et al.
Foilsithe / Cruthaithe: (2016-07-01)

Effects of Metformin on Hepatic Steatosis in Adults with Nonalcoholic Fatty Liver Disease and Diabetes: Insights from the Cellular to Patient Levels
de réir: Kanokwan Pinyopornpanish, et al.
Foilsithe / Cruthaithe: (2021-11-01)

Iron, hepatitis C virus and hepatic steatosis
de réir: J. A. Solís Herruzo, et al.

The efficacy of antiviral treatment in chronic hepatitis B patients with hepatic steatosis
de réir: Danqing Hu, et al.
Foilsithe / Cruthaithe: (2024-04-01)

Protective effect of bile acids on the onset of fructose-induced hepatic steatosis in mice
de réir: Valentina Volynets, et al.
Foilsithe / Cruthaithe: (2010-12-01)

Similar insulin regulation of splanchnic FFA and VLDL-TG in men with nonalcoholic hepatic steatosis and steatohepatitis
de réir: Jeyanthini Risikesan, et al.
Foilsithe / Cruthaithe: (2024-07-01)

PPAR𝛼 Is Required for PPAR𝛿 Action in Regulation of Body Weight and Hepatic Steatosis in Mice
de réir: Garbacz, Wojciech G., et al.
Foilsithe / Cruthaithe: (2015)

Mechanistic studies of PEG-asparaginase-induced liver injury and hepatic steatosis in mice
de réir: Gundala Venkata Naveen Kumar, et al.
Foilsithe / Cruthaithe: (2021-12-01)

Inflammatory Mediators of Hepatic Steatosis
de réir: Elizabeth Hijona, et al.
Foilsithe / Cruthaithe: (2010-01-01)

Recognition of Diffuse Hepatic Steatosis
de réir: Danil Yevdokimov, et al.
Foilsithe / Cruthaithe: (2023-05-01)

Hepatic steatosis in patients with acromegaly
de réir: Andreani Koutsou‐Tassopoulou, et al.
Foilsithe / Cruthaithe: (2019-10-01)

Fish oil and indomethacin in combination potently reduce dyslipidemia and hepatic steatosis in LDLR −/− mice
de réir: Ganesan Murali, et al.
Foilsithe / Cruthaithe: (2012-10-01)

Modifying nutritional substrates induces macrovesicular lipid droplet accumulation and metabolic alterations in a cellular model of hepatic steatosis
de réir: Gunn, P, et al.
Foilsithe / Cruthaithe: (2020)

Hepatic steatosis and its relationship to transplantation.
de réir: Imber, C, et al.
Foilsithe / Cruthaithe: (2002)

Short-Term Metformin Treatment Enriches Bacteroides dorei in an Obese Liver Steatosis Zucker Rat Model
de réir: Michael S. Robeson, et al.
Foilsithe / Cruthaithe: (2022-03-01)