Analysis of adhesive domains from the A4VAR Plasmodium falciparum erythrocyte membrane protein-1 identifies a CD36 binding domain.

The A4VAR is a variant antigen expressed by a clonal line that binds CD36 and intercellular adhesion molecule-1, ICAM-1. We have cloned and sequenced the extracellular domain coded by the A4var gene. To probe the relationship between A4var expression and parasite adhesion to ICAM-1, var mRNA and pro...

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Hlavní autoři: Smith, J, Kyes, S, Craig, A, Fagan, T, Hudson-Taylor, D, Miller, L, Baruch, D, Newbold, C
Médium: Journal article
Jazyk:English
Vydáno: 1998