Genetic heterogeneity of Australian Candida auris isolates: insights from a nonoutbreak setting using whole-genome sequencing

Whole-genome sequencing clustered Australian Candida auris isolates from sporadic cases within clade III. Case isolates were genomically distinct; however, unexpectedly, those from 1 case comprised 2 groups separated by >60 single nucleotide polymorphisms (SNPs) with no isolate being identica...

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Bibliografische gegevens
Hoofdauteurs: Biswas, C, Wang, Q, van Hal, SJ, Eyre, DW, Hudson, B, Halliday, CL, Mazsewska, K, Kizny Gordon, A, Lee, A, Irinyi, L, Heath, CH, Chakrabarti, A, Govender, NP, Meyer, W, Sintchenko, V, Chen, SC-A
Formaat: Journal article
Taal:English
Gepubliceerd in: Oxford University Press 2020
Omschrijving
Samenvatting:Whole-genome sequencing clustered Australian Candida auris isolates from sporadic cases within clade III. Case isolates were genomically distinct; however, unexpectedly, those from 1 case comprised 2 groups separated by >60 single nucleotide polymorphisms (SNPs) with no isolate being identical, in contrast to outbreaks where isolates from any 1 individual have differed by <3 SNPs. Multidrug resistance was absent. High within-host genetic heterogeneity should be considered when investigating C. auris infections.