Genetic heterogeneity of Australian Candida auris isolates: insights from a nonoutbreak setting using whole-genome sequencing
Whole-genome sequencing clustered Australian Candida auris isolates from sporadic cases within clade III. Case isolates were genomically distinct; however, unexpectedly, those from 1 case comprised 2 groups separated by >60 single nucleotide polymorphisms (SNPs) with no isolate being identica...
| Egile Nagusiak: | , , , , , , , , , , , , , , , |
|---|---|
| Formatua: | Journal article |
| Hizkuntza: | English |
| Argitaratua: |
Oxford University Press
2020
|
| _version_ | 1826297252388274176 |
|---|---|
| author | Biswas, C Wang, Q van Hal, SJ Eyre, DW Hudson, B Halliday, CL Mazsewska, K Kizny Gordon, A Lee, A Irinyi, L Heath, CH Chakrabarti, A Govender, NP Meyer, W Sintchenko, V Chen, SC-A |
| author_facet | Biswas, C Wang, Q van Hal, SJ Eyre, DW Hudson, B Halliday, CL Mazsewska, K Kizny Gordon, A Lee, A Irinyi, L Heath, CH Chakrabarti, A Govender, NP Meyer, W Sintchenko, V Chen, SC-A |
| author_sort | Biswas, C |
| collection | OXFORD |
| description | Whole-genome sequencing clustered Australian Candida auris isolates from sporadic cases within clade III. Case isolates were genomically distinct; however, unexpectedly, those from 1 case comprised 2 groups separated by >60 single nucleotide polymorphisms (SNPs) with no isolate being identical, in contrast to outbreaks where isolates from any 1 individual have differed by <3 SNPs. Multidrug resistance was absent. High within-host genetic heterogeneity should be considered when investigating C. auris infections. |
| first_indexed | 2024-03-07T04:28:44Z |
| format | Journal article |
| id | oxford-uuid:cd929516-7f06-4446-b51d-172716a6390d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:28:44Z |
| publishDate | 2020 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:cd929516-7f06-4446-b51d-172716a6390d2022-03-27T07:29:41ZGenetic heterogeneity of Australian Candida auris isolates: insights from a nonoutbreak setting using whole-genome sequencing Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:cd929516-7f06-4446-b51d-172716a6390dEnglishSymplectic ElementsOxford University Press2020Biswas, CWang, Qvan Hal, SJEyre, DWHudson, BHalliday, CLMazsewska, KKizny Gordon, ALee, AIrinyi, LHeath, CHChakrabarti, AGovender, NPMeyer, WSintchenko, VChen, SC-AWhole-genome sequencing clustered Australian Candida auris isolates from sporadic cases within clade III. Case isolates were genomically distinct; however, unexpectedly, those from 1 case comprised 2 groups separated by >60 single nucleotide polymorphisms (SNPs) with no isolate being identical, in contrast to outbreaks where isolates from any 1 individual have differed by <3 SNPs. Multidrug resistance was absent. High within-host genetic heterogeneity should be considered when investigating C. auris infections. |
| spellingShingle | Biswas, C Wang, Q van Hal, SJ Eyre, DW Hudson, B Halliday, CL Mazsewska, K Kizny Gordon, A Lee, A Irinyi, L Heath, CH Chakrabarti, A Govender, NP Meyer, W Sintchenko, V Chen, SC-A Genetic heterogeneity of Australian Candida auris isolates: insights from a nonoutbreak setting using whole-genome sequencing |
| title | Genetic heterogeneity of Australian Candida auris isolates: insights from a nonoutbreak setting using whole-genome sequencing |
| title_full | Genetic heterogeneity of Australian Candida auris isolates: insights from a nonoutbreak setting using whole-genome sequencing |
| title_fullStr | Genetic heterogeneity of Australian Candida auris isolates: insights from a nonoutbreak setting using whole-genome sequencing |
| title_full_unstemmed | Genetic heterogeneity of Australian Candida auris isolates: insights from a nonoutbreak setting using whole-genome sequencing |
| title_short | Genetic heterogeneity of Australian Candida auris isolates: insights from a nonoutbreak setting using whole-genome sequencing |
| title_sort | genetic heterogeneity of australian candida auris isolates insights from a nonoutbreak setting using whole genome sequencing |
| work_keys_str_mv | AT biswasc geneticheterogeneityofaustraliancandidaaurisisolatesinsightsfromanonoutbreaksettingusingwholegenomesequencing AT wangq geneticheterogeneityofaustraliancandidaaurisisolatesinsightsfromanonoutbreaksettingusingwholegenomesequencing AT vanhalsj geneticheterogeneityofaustraliancandidaaurisisolatesinsightsfromanonoutbreaksettingusingwholegenomesequencing AT eyredw geneticheterogeneityofaustraliancandidaaurisisolatesinsightsfromanonoutbreaksettingusingwholegenomesequencing AT hudsonb geneticheterogeneityofaustraliancandidaaurisisolatesinsightsfromanonoutbreaksettingusingwholegenomesequencing AT hallidaycl geneticheterogeneityofaustraliancandidaaurisisolatesinsightsfromanonoutbreaksettingusingwholegenomesequencing AT mazsewskak geneticheterogeneityofaustraliancandidaaurisisolatesinsightsfromanonoutbreaksettingusingwholegenomesequencing AT kiznygordona geneticheterogeneityofaustraliancandidaaurisisolatesinsightsfromanonoutbreaksettingusingwholegenomesequencing AT leea geneticheterogeneityofaustraliancandidaaurisisolatesinsightsfromanonoutbreaksettingusingwholegenomesequencing AT irinyil geneticheterogeneityofaustraliancandidaaurisisolatesinsightsfromanonoutbreaksettingusingwholegenomesequencing AT heathch geneticheterogeneityofaustraliancandidaaurisisolatesinsightsfromanonoutbreaksettingusingwholegenomesequencing AT chakrabartia geneticheterogeneityofaustraliancandidaaurisisolatesinsightsfromanonoutbreaksettingusingwholegenomesequencing AT govendernp geneticheterogeneityofaustraliancandidaaurisisolatesinsightsfromanonoutbreaksettingusingwholegenomesequencing AT meyerw geneticheterogeneityofaustraliancandidaaurisisolatesinsightsfromanonoutbreaksettingusingwholegenomesequencing AT sintchenkov geneticheterogeneityofaustraliancandidaaurisisolatesinsightsfromanonoutbreaksettingusingwholegenomesequencing AT chensca geneticheterogeneityofaustraliancandidaaurisisolatesinsightsfromanonoutbreaksettingusingwholegenomesequencing |