Glucose analogue inhibitors of glycogen phosphorylase: from crystallographic analysis to drug prediction using GRID force-field and GOLPE variable selection.

Glucose analogue inhibitors of glycogen phosphorylase: from crystallographic analysis to drug prediction using GRID force-field and GOLPE variable selection.

Several inhibitors of the large regulatory enzyme glycogen phosphorylase (GP) have been studied in crystallographic and kinetic experiments. GP catalyses the first step in the phosphorylysis of glycogen to glucose-l-phosphate, which is utilized via glycolysis to provide energy to sustain muscle cont...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Watson, K, Mitchell, E, Johnson, L, Cruciani, G, Son, J, Bichard, C, Fleet, G, Oikonomakos, N, Kontou, M, Zographos, SE
Formatua:	Conference item
Argitaratua:	1995

Antzeko izenburuak

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Kinetic and crystallographic studies of glucopyranose spirohydantoin and glucopyranosylamine analogs inhibitors of glycogen phosphorylase.
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Argitaratua: (2005)

INHIBITORS OF GLYCOGEN-PHOSPHORYLASE
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Argitaratua: (1994)

N-acetyl-beta-D-glucopyranosylamine: a potent T-state inhibitor of glycogen phosphorylase. A comparison with alpha-D-glucose.
nork: Oikonomakos, N, et al.
Argitaratua: (1995)

GLUCOSE ANALOG INHIBITORS OF GLYCOGEN-PHOSPHORYLASE
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Argitaratua: (1994)

POTENT INHIBITION OF GLYCOGEN-PHOSPHORYLASE BY A SPIROHYDANTOIN OF GLUCOPYRANOSE - FIRST PYRANOSE ANALOGS OF HYDANTOCIDIN
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Argitaratua: (1995)

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Stereospecific synthesis of spirohydantoins of beta-glucopyranose: Inhibitors of glycogen phosphorylase
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Triazole carboxylic acids as anionic sugar mimics? Inhibition of glycogen phosphorylase by a D-glucotriazole carboxylate
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Argitaratua: (1997)

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Argitaratua: (1989)

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Argitaratua: (1984)

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Argitaratua: (1987)

The structure of phosphorylase kinase holoenzyme at 9.9 angstroms resolution and location of the catalytic subunit and the substrate glycogen phosphorylase.
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Argitaratua: (2009)

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Argitaratua: (1991)

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nork: Duke, E, et al.
Argitaratua: (1991)

X-RAY CRYSTALLOGRAPHIC ANALYSIS OF 2,6-ANHYDRO-N-METHYL-D-GLYCERO-D-IDO-HEPTONAMIDE - THE 1ST EXAMPLE OF A SIMPLE GLUCOSE ANALOG WITH A SKEW BOAT STRUCTURE
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Argitaratua: (1993)

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Argitaratua: (1996)

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nork: Busby, S
Argitaratua: (1975)

The structure of a glycogen phosphorylase glucopyranose spirohydantoin complex at 1.8 A resolution and 100 K: the role of the water structure and its contribution to binding.
nork: Gregoriou, M, et al.
Argitaratua: (1998)

Uridine(5')diphospho(1)-alpha-D-glucose. A binding study to glycogen phosphorylase b in the crystal.
nork: Oikonomakos, N, et al.
Argitaratua: (1988)

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Argitaratua: (2023-03-01)

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On the promise of glycogen phosphorylase inhibition in acute inflammation
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Argitaratua: (2021-03-01)

Transcriptional regulation of rat brain glycogen phosphorylase
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Argitaratua: (2007-03-01)

Glucofuranose analogues of hydantocidin
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Argitaratua: (1996)

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Mitochondrial Redox Status Regulates Glycogen Metabolism via Glycogen Phosphorylase Activity
nork: Ikko Sakamoto, et al.
Argitaratua: (2024-11-01)

Physicochemical and Spectroscopic Characterization of Glycogen and Glycogen Phosphorylase <i>b</i> Complexes
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Argitaratua: (2024-07-01)

Three-dimensional structure of phosphorylase kinase at 22 A resolution and its complex with glycogen phosphorylase b.
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Argitaratua: (2002)