Glucose analogue inhibitors of glycogen phosphorylase: from crystallographic analysis to drug prediction using GRID force-field and GOLPE variable selection.

Glucose analogue inhibitors of glycogen phosphorylase: from crystallographic analysis to drug prediction using GRID force-field and GOLPE variable selection.

Several inhibitors of the large regulatory enzyme glycogen phosphorylase (GP) have been studied in crystallographic and kinetic experiments. GP catalyses the first step in the phosphorylysis of glycogen to glucose-l-phosphate, which is utilized via glycolysis to provide energy to sustain muscle cont...

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التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Watson, K, Mitchell, E, Johnson, L, Cruciani, G, Son, J, Bichard, C, Fleet, G, Oikonomakos, N, Kontou, M, Zographos, SE
التنسيق: Conference item
منشور في: 1995

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