Glucose analogue inhibitors of glycogen phosphorylase: from crystallographic analysis to drug prediction using GRID force-field and GOLPE variable selection.

Glucose analogue inhibitors of glycogen phosphorylase: from crystallographic analysis to drug prediction using GRID force-field and GOLPE variable selection.

Several inhibitors of the large regulatory enzyme glycogen phosphorylase (GP) have been studied in crystallographic and kinetic experiments. GP catalyses the first step in the phosphorylysis of glycogen to glucose-l-phosphate, which is utilized via glycolysis to provide energy to sustain muscle cont...

Bibliográfalaš dieđut
Váldodahkkit:	Watson, K, Mitchell, E, Johnson, L, Cruciani, G, Son, J, Bichard, C, Fleet, G, Oikonomakos, N, Kontou, M, Zographos, SE
Materiálatiipa:	Conference item
Almmustuhtton:	1995

Geahča maid

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Dahkki: Oikonomakos, N, et al.
Almmustuhtton: (1994)

Kinetic and crystallographic studies of glucopyranose spirohydantoin and glucopyranosylamine analogs inhibitors of glycogen phosphorylase.
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Almmustuhtton: (2005)

INHIBITORS OF GLYCOGEN-PHOSPHORYLASE
Dahkki: Bichard, C, et al.
Almmustuhtton: (1994)

N-acetyl-beta-D-glucopyranosylamine: a potent T-state inhibitor of glycogen phosphorylase. A comparison with alpha-D-glucose.
Dahkki: Oikonomakos, N, et al.
Almmustuhtton: (1995)

GLUCOSE ANALOG INHIBITORS OF GLYCOGEN-PHOSPHORYLASE
Dahkki: Johnson, L, et al.
Almmustuhtton: (1994)

POTENT INHIBITION OF GLYCOGEN-PHOSPHORYLASE BY A SPIROHYDANTOIN OF GLUCOPYRANOSE - FIRST PYRANOSE ANALOGS OF HYDANTOCIDIN
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Almmustuhtton: (1995)

Glucopyranose spirohydantoins: Specific inhibitors of glycogen phosphorylase
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Almmustuhtton: (1997)

Effects of commonly used cryoprotectants on glycogen phosphorylase activity and structure.
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Almmustuhtton: (1999)

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Almmustuhtton: (1994)

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Almmustuhtton: (1995)

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Almmustuhtton: (1989)

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Dahkki: Mitchell, E
Almmustuhtton: (1994)

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Almmustuhtton: (1987)

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Almmustuhtton: (1984)

Catalysis in the crystal: synchrotron radiation studies with glycogen phosphorylase b.
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Almmustuhtton: (1987)

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Almmustuhtton: (1991)

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Almmustuhtton: (1991)

TOWARDS TIME-RESOLVED DIFFRACTION STUDIES WITH GLYCOGEN-PHOSPHORYLASE
Dahkki: Duke, E, et al.
Almmustuhtton: (1991)

X-RAY CRYSTALLOGRAPHIC ANALYSIS OF 2,6-ANHYDRO-N-METHYL-D-GLYCERO-D-IDO-HEPTONAMIDE - THE 1ST EXAMPLE OF A SIMPLE GLUCOSE ANALOG WITH A SKEW BOAT STRUCTURE
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Almmustuhtton: (1993)

A galactopyranose analogue of hydantocidin
Dahkki: Brandstetter, T, et al.
Almmustuhtton: (1996)

Studies on the glycogen phosphorylase system
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Almmustuhtton: (1975)

The structure of a glycogen phosphorylase glucopyranose spirohydantoin complex at 1.8 A resolution and 100 K: the role of the water structure and its contribution to binding.
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Almmustuhtton: (1998)

Uridine(5')diphospho(1)-alpha-D-glucose. A binding study to glycogen phosphorylase b in the crystal.
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Almmustuhtton: (1988)

Substrate-cofactor interactions for glycogen phosphorylase b: a binding study in the crystal with heptenitol and heptulose 2-phosphate.
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Almmustuhtton: (1984)

Comparison of AMP and NADH binding to glycogen phosphorylase b.
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Almmustuhtton: (1983)

The role of glycogen phosphorylase in glycogen biogenesis in skeletal muscle after exercise
Dahkki: Abram Katz
Almmustuhtton: (2023-03-01)

Structural changes in glycogen phosphorylase induced by phosphorylation.
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Almmustuhtton: (1988)

On the promise of glycogen phosphorylase inhibition in acute inflammation
Dahkki: Aarooran Sivakumaran Durairaj, et al.
Almmustuhtton: (2021-03-01)

Transcriptional regulation of rat brain glycogen phosphorylase
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Almmustuhtton: (2007-03-01)

Glucofuranose analogues of hydantocidin
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Almmustuhtton: (1996)

Pyridoxal phosphate site in glycogen phosphorylase b: structure in native enzyme and in three derivatives with modified cofactors.
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Almmustuhtton: (1987)

Mitochondrial Redox Status Regulates Glycogen Metabolism via Glycogen Phosphorylase Activity
Dahkki: Ikko Sakamoto, et al.
Almmustuhtton: (2024-11-01)

Physicochemical and Spectroscopic Characterization of Glycogen and Glycogen Phosphorylase <i>b</i> Complexes
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Almmustuhtton: (2024-07-01)

Three-dimensional structure of phosphorylase kinase at 22 A resolution and its complex with glycogen phosphorylase b.
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Almmustuhtton: (2002)