Glucose analogue inhibitors of glycogen phosphorylase: from crystallographic analysis to drug prediction using GRID force-field and GOLPE variable selection.

Glucose analogue inhibitors of glycogen phosphorylase: from crystallographic analysis to drug prediction using GRID force-field and GOLPE variable selection.

Several inhibitors of the large regulatory enzyme glycogen phosphorylase (GP) have been studied in crystallographic and kinetic experiments. GP catalyses the first step in the phosphorylysis of glycogen to glucose-l-phosphate, which is utilized via glycolysis to provide energy to sustain muscle cont...

Detaylı Bibliyografya
Asıl Yazarlar:	Watson, K, Mitchell, E, Johnson, L, Cruciani, G, Son, J, Bichard, C, Fleet, G, Oikonomakos, N, Kontou, M, Zographos, SE
Materyal Türü:	Conference item
Baskı/Yayın Bilgisi:	1995

Benzer Materyaller

The design of potential antidiabetic drugs: experimental investigation of a number of beta-D-glucose analogue inhibitors of glycogen phosphorylase.
Yazar:: Oikonomakos, N, ve diğerleri
Baskı/Yayın Bilgisi: (1994)

Kinetic and crystallographic studies of glucopyranose spirohydantoin and glucopyranosylamine analogs inhibitors of glycogen phosphorylase.
Yazar:: Watson, K, ve diğerleri
Baskı/Yayın Bilgisi: (2005)

INHIBITORS OF GLYCOGEN-PHOSPHORYLASE
Yazar:: Bichard, C, ve diğerleri
Baskı/Yayın Bilgisi: (1994)

N-acetyl-beta-D-glucopyranosylamine: a potent T-state inhibitor of glycogen phosphorylase. A comparison with alpha-D-glucose.
Yazar:: Oikonomakos, N, ve diğerleri
Baskı/Yayın Bilgisi: (1995)

GLUCOSE ANALOG INHIBITORS OF GLYCOGEN-PHOSPHORYLASE
Yazar:: Johnson, L, ve diğerleri
Baskı/Yayın Bilgisi: (1994)

POTENT INHIBITION OF GLYCOGEN-PHOSPHORYLASE BY A SPIROHYDANTOIN OF GLUCOPYRANOSE - FIRST PYRANOSE ANALOGS OF HYDANTOCIDIN
Yazar:: Bichard, C, ve diğerleri
Baskı/Yayın Bilgisi: (1995)

Glucopyranose spirohydantoins: Specific inhibitors of glycogen phosphorylase
Yazar:: delaFuente, C, ve diğerleri
Baskı/Yayın Bilgisi: (1997)

Effects of commonly used cryoprotectants on glycogen phosphorylase activity and structure.
Yazar:: Tsitsanou, K, ve diğerleri
Baskı/Yayın Bilgisi: (1999)

Design of inhibitors of glycogen phosphorylase: a study of alpha- and beta-C-glucosides and 1-thio-beta-D-glucose compounds.
Yazar:: Watson, K, ve diğerleri
Baskı/Yayın Bilgisi: (1994)

Stereospecific synthesis of spirohydantoins of beta-glucopyranose: Inhibitors of glycogen phosphorylase
Yazar:: Krulle, T, ve diğerleri
Baskı/Yayın Bilgisi: (1997)

Glucose analogue inhibitors of glycogen phosphorylase: the design of potential drugs for diabetes.
Yazar:: Martin, J, ve diğerleri
Baskı/Yayın Bilgisi: (1991)

SPECIFIC-INHIBITION OF GLYCOGEN-PHOSPHORYLASE BY A SPIRODIKETOPIPERAZINE AT THE ANOMERIC POSITION OF GLUCOPYRANOSE
Yazar:: Krulle, T, ve diğerleri
Baskı/Yayın Bilgisi: (1995)

Triazole carboxylic acids as anionic sugar mimics? Inhibition of glycogen phosphorylase by a D-glucotriazole carboxylate
Yazar:: Krulle, T, ve diğerleri
Baskı/Yayın Bilgisi: (1997)

X-ray crystallographic studies of glycogen phosphorylase b
Yazar:: Wild, D, ve diğerleri
Baskı/Yayın Bilgisi: (1981)

Effects of C-1-substituted glucose analogue on the activation states of glycogen synthase and glycogen phosphorylase in rat hepatocytes.
Yazar:: Board, M, ve diğerleri
Baskı/Yayın Bilgisi: (1995)

The binding of beta-glycerophosphate to glycogen phosphorylase b in the crystal.
Yazar:: Oikonomakos, N, ve diğerleri
Baskı/Yayın Bilgisi: (1989)

Cryocrystallographic and mechanistic studies on glycogen phosphorylase
Yazar:: Mitchell, E
Baskı/Yayın Bilgisi: (1994)

Phosphate-recognition sites in catalysis and control of glycogen phosphorylase b.
Yazar:: Johnson, L, ve diğerleri
Baskı/Yayın Bilgisi: (1987)

Allosteric interactions of glycogen phosphorylase b. A crystallographic study of glucose 6-phosphate and inorganic phosphate binding to di-imidate-cross-linked phosphorylase b.
Yazar:: Lorek, A, ve diğerleri
Baskı/Yayın Bilgisi: (1984)

Catalysis in the crystal: synchrotron radiation studies with glycogen phosphorylase b.
Yazar:: Hajdu, J, ve diğerleri
Baskı/Yayın Bilgisi: (1987)

The structure of phosphorylase kinase holoenzyme at 9.9 angstroms resolution and location of the catalytic subunit and the substrate glycogen phosphorylase.
Yazar:: Vénien-Bryan, C, ve diğerleri
Baskı/Yayın Bilgisi: (2009)

Towards time-resolved diffraction studies with glycogen phosphorylase.
Yazar:: Duke, E, ve diğerleri
Baskı/Yayın Bilgisi: (1991)

TOWARDS TIME-RESOLVED DIFFRACTION STUDIES WITH GLYCOGEN-PHOSPHORYLASE
Yazar:: Duke, E, ve diğerleri
Baskı/Yayın Bilgisi: (1991)

TOWARDS TIME-RESOLVED DIFFRACTION STUDIES WITH GLYCOGEN-PHOSPHORYLASE
Yazar:: Duke, E, ve diğerleri
Baskı/Yayın Bilgisi: (1991)

X-RAY CRYSTALLOGRAPHIC ANALYSIS OF 2,6-ANHYDRO-N-METHYL-D-GLYCERO-D-IDO-HEPTONAMIDE - THE 1ST EXAMPLE OF A SIMPLE GLUCOSE ANALOG WITH A SKEW BOAT STRUCTURE
Yazar:: Watson, K, ve diğerleri
Baskı/Yayın Bilgisi: (1993)

A galactopyranose analogue of hydantocidin
Yazar:: Brandstetter, T, ve diğerleri
Baskı/Yayın Bilgisi: (1996)

Studies on the glycogen phosphorylase system
Yazar:: Busby, S
Baskı/Yayın Bilgisi: (1975)

The structure of a glycogen phosphorylase glucopyranose spirohydantoin complex at 1.8 A resolution and 100 K: the role of the water structure and its contribution to binding.
Yazar:: Gregoriou, M, ve diğerleri
Baskı/Yayın Bilgisi: (1998)

Uridine(5')diphospho(1)-alpha-D-glucose. A binding study to glycogen phosphorylase b in the crystal.
Yazar:: Oikonomakos, N, ve diğerleri
Baskı/Yayın Bilgisi: (1988)

Substrate-cofactor interactions for glycogen phosphorylase b: a binding study in the crystal with heptenitol and heptulose 2-phosphate.
Yazar:: McLaughlin, P, ve diğerleri
Baskı/Yayın Bilgisi: (1984)

Comparison of AMP and NADH binding to glycogen phosphorylase b.
Yazar:: Stura, E, ve diğerleri
Baskı/Yayın Bilgisi: (1983)

The role of glycogen phosphorylase in glycogen biogenesis in skeletal muscle after exercise
Yazar:: Abram Katz
Baskı/Yayın Bilgisi: (2023-03-01)

Structural changes in glycogen phosphorylase induced by phosphorylation.
Yazar:: Sprang, SR, ve diğerleri
Baskı/Yayın Bilgisi: (1988)

On the promise of glycogen phosphorylase inhibition in acute inflammation
Yazar:: Aarooran Sivakumaran Durairaj, ve diğerleri
Baskı/Yayın Bilgisi: (2021-03-01)

Transcriptional regulation of rat brain glycogen phosphorylase
Yazar:: Hamprecht Bernd, ve diğerleri
Baskı/Yayın Bilgisi: (2007-03-01)

Glucofuranose analogues of hydantocidin
Yazar:: Brandstetter, T, ve diğerleri
Baskı/Yayın Bilgisi: (1996)

Pyridoxal phosphate site in glycogen phosphorylase b: structure in native enzyme and in three derivatives with modified cofactors.
Yazar:: Oikonomakos, N, ve diğerleri
Baskı/Yayın Bilgisi: (1987)

Mitochondrial Redox Status Regulates Glycogen Metabolism via Glycogen Phosphorylase Activity
Yazar:: Ikko Sakamoto, ve diğerleri
Baskı/Yayın Bilgisi: (2024-11-01)

Physicochemical and Spectroscopic Characterization of Glycogen and Glycogen Phosphorylase <i>b</i> Complexes
Yazar:: Pandora Karakousi, ve diğerleri
Baskı/Yayın Bilgisi: (2024-07-01)

Three-dimensional structure of phosphorylase kinase at 22 A resolution and its complex with glycogen phosphorylase b.
Yazar:: Vénien-Bryan, C, ve diğerleri
Baskı/Yayın Bilgisi: (2002)