Investigating the PIP2 Binding Site in Kir Channels Via Multi-Scale Biomolecular Simulations

Investigating the PIP2 Binding Site in Kir Channels Via Multi-Scale Biomolecular Simulations

Xehetasun bibliografikoak
Egile Nagusiak:	Stansfeld, P, Hopkinson, R, Ashcroft, F, Sansom, M
Formatua:	Journal article
Argitaratua:	2010

Antzeko izenburuak

PIP(2)-binding site in Kir channels: definition by multiscale biomolecular simulations.
nork: Stansfeld, P, et al.
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PIP2-binding site in Kir channels: definition by multiscale biomolecular simulations
nork: Stansfeld, P, et al.
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Identification of the PIP2-binding site on Kir6.2 by molecular modelling and functional analysis.
nork: Haider, S, et al.
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Ion-blocking sites of the Kir2.1 channel revealed by multiscale modeling.
nork: Tai, K, et al.
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Simulating PIP2-Induced Gating Transitions in Kir6.2 Channels
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Identification of residues contributing to the ATP binding site of Kir6.2.
nork: Trapp, S, et al.
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Functional analysis of a structural model of the ATP-binding site of the KATP channel Kir6.2 subunit.
nork: Antcliff, J, et al.
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Conformational rearrangements during PIP2 gating in Kir channels
nork: Rapedius, M, et al.
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Mapping the architecture of the ATP-binding site of the KATP channel subunit Kir6.2.
nork: Dabrowski, M, et al.
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Conformational dynamics of the ligand-binding domain of inward rectifier K channels as revealed by molecular dynamics simulations: toward an understanding of Kir channel gating.
nork: Haider, S, et al.
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Control of pH and PIP2 gating in heteromeric Kir4.1/Kir5.1 channels by H-Bonding at the helix-bundle crossing.
nork: Rapedius, M, et al.
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Molecular dynamics simulations of inwardly rectifying (Kir) potassium channels: a comparative study.
nork: Haider, S, et al.
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Structure of an open KATP channel reveals tandem PIP2 binding sites mediating the Kir6.2 and SUR1 regulatory interface
nork: Camden M. Driggers, et al.
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Interplay Between Lipid Modulators of Kir2 Channels: Cholesterol and PIP2
nork: Avia Rosenhouse-Dantsker, et al.
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Mapping the architecture of the ATP-binding site of Kir6.2
nork: Dabrowski, M, et al.
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Filter flexibility in a mammalian K channel: models and simulations of Kir6.2 mutants.
nork: Capener, C, et al.
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A conserved tryptophan at the membrane-water interface acts as a gatekeeper for Kir6.2/SUR1 channels and causes neonatal diabetes when mutated.
nork: Männikkö, R, et al.
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Ion channels - Exciting times for PIP2
nork: Ashcroft, F
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A mutation in the ATP-binding site of the Kir6.2 subunit of the KATP channel alters coupling with the SUR2A subunit.
nork: Tammaro, P, et al.
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Andersen–Tawil Syndrome Is Associated With Impaired PIP2 Regulation of the Potassium Channel Kir2.1
nork: Reem Handklo-Jamal, et al.
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Modulation of the IKS channel by PIP2 requires two binding sites per monomer
nork: Audrey Deyawe Kongmeneck, et al.
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Focus on Kir6.2: a key component of the ATP-sensitive potassium channel.
nork: Haider, S, et al.
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Simulation-based prediction of phosphatidylinositol 4,5-bisphosphate binding to an ion channel.
nork: Schmidt, MR, et al.
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Multiple sites of interaction between the intracellular domains of an inwardly rectifying potassium channel, Kir6.2.
nork: Jones, P, et al.
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Time-dependent activation of Kir6.2/SUR2A channels but not Kir6.2/SUR1 channels in the presence of ATP
nork: Ashcroft, F, et al.
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Time-dependent activation of KIR6.2/SUR2A channels but not KIR6.2/SUR1 channels in the presence of MgATP
nork: Song, D, et al.
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Glimepiride block of Kir6.2/SUR1 Kir6.2/SUR2A and Kir6.2/SUR2A and Kir6.2/SUR2B K-ATP channels.
nork: Ashcroft, F, et al.
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Kir6.2-dependent high-affinity repaglinide binding to beta-cell K(ATP) channels.
nork: Hansen, A, et al.
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Phentolamine block of KATP channels is mediated by Kir6.2.
nork: Proks, P, et al.
Argitaratua: (1997)

Computer modelling and simulation studies of a human inwardly rectifying potassium channel Kir6.2
nork: Capener, C, et al.
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Conformational dynamics of M2 helices in KirBac channels: helix flexibility in relation to gating via molecular dynamics simulations.
nork: Grottesi, A, et al.
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Exciting times for PIP2.
nork: Ashcroft, F
Argitaratua: (1998)

PIP2 and PIP as determinants for ATP inhibition of KATP channels.
nork: Baukrowitz, T, et al.
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K2P and Kir K+ Channels in Physiological Bilayers
nork: Schmidt, MR, et al.
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Membrane recognition and binding by the phosphatidylinositol phosphate kinase PIP5K1A: a multiscale simulation study
nork: Amos, S-BTA, et al.
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Quality assurance for biomolecular simulations
nork: Murdock, SE, et al.
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Effects of mitiglinide (S 21403) on Kir6.2/SUR1, Kir6.2/SUR2A and Kir6.2/SUR2B types of ATP-sensitive potassium channel.
nork: Reimann, F, et al.
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Permeation and gating in KirBac: Molecular dynamics simulations
nork: Grottesi, A, et al.
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Grid computing and biomolecular simulation.
nork: Woods, C, et al.
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Filter flexibility and distortion in a bacterial inward rectifier K+ channel: simulation studies of KirBac1.1.
nork: Domene, C, et al.
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