Apoptotic bone marrow CD34+ cells in cirrhotic patients.
AIM: To access the frequency and level of apoptotic CD34+ cells isolated from the marrow fluid of patients with post-hepatitis cirrhosis. METHODS: The frequency of bone marrow CD34+ cells and apoptotic bone marrow CD34+ cells in 31 in-patients with post-hepatitis cirrhosis (cirrhosis group), and 15...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2011
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| _version_ | 1797095515360329728 |
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| author | Dang, S Wang, W Gao, N Wang, S Li, M Liu, L Sun, M Dong, T |
| author_facet | Dang, S Wang, W Gao, N Wang, S Li, M Liu, L Sun, M Dong, T |
| author_sort | Dang, S |
| collection | OXFORD |
| description | AIM: To access the frequency and level of apoptotic CD34+ cells isolated from the marrow fluid of patients with post-hepatitis cirrhosis. METHODS: The frequency of bone marrow CD34+ cells and apoptotic bone marrow CD34+ cells in 31 in-patients with post-hepatitis cirrhosis (cirrhosis group), and 15 out-patients without liver or blood disorders (control group) was calculated by flow cytometry. Parameters were collected to evaluate liver functions of patients in cirrhosis group. RESULTS: The percentage of normal bone marrow CD34+ cells was 6.30% ± 2.48% and 1.87% ± 0.53% (t = 3.906, P < 0.01) while that of apoptotic marrow CD34+ cells was 15.00% ± 15.81% and 5.73% ± 1.57% (t = 2.367, P < 0.05) in cirrhosis and control groups, respectively. The percentage of apoptotic marrow CD34+ cells was 6.25% ± 3.30% and 20.92 ± 18.5% (t = 2.409, P < 0.05) in Child-Pugh A and Child-Pugh B + C cirrhotic patients, respectively. The percentage of late apoptotic marrow CD34+ cells was positively correlated with the total bilirubin and aspartate aminotransferase serum levels in patients with cirrhosis. CONCLUSION: The status of CD34+ marrow cells in cirrhotic patients may suggest that the ability of hematopoietic progenitor cells to transform into mature blood cells is impaired. |
| first_indexed | 2024-03-07T04:28:56Z |
| format | Journal article |
| id | oxford-uuid:cda5870c-83a0-48f5-81e8-13f8ded5a184 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:28:56Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:cda5870c-83a0-48f5-81e8-13f8ded5a1842022-03-27T07:30:06ZApoptotic bone marrow CD34+ cells in cirrhotic patients.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:cda5870c-83a0-48f5-81e8-13f8ded5a184EnglishSymplectic Elements at Oxford2011Dang, SWang, WGao, NWang, SLi, MLiu, LSun, MDong, TAIM: To access the frequency and level of apoptotic CD34+ cells isolated from the marrow fluid of patients with post-hepatitis cirrhosis. METHODS: The frequency of bone marrow CD34+ cells and apoptotic bone marrow CD34+ cells in 31 in-patients with post-hepatitis cirrhosis (cirrhosis group), and 15 out-patients without liver or blood disorders (control group) was calculated by flow cytometry. Parameters were collected to evaluate liver functions of patients in cirrhosis group. RESULTS: The percentage of normal bone marrow CD34+ cells was 6.30% ± 2.48% and 1.87% ± 0.53% (t = 3.906, P < 0.01) while that of apoptotic marrow CD34+ cells was 15.00% ± 15.81% and 5.73% ± 1.57% (t = 2.367, P < 0.05) in cirrhosis and control groups, respectively. The percentage of apoptotic marrow CD34+ cells was 6.25% ± 3.30% and 20.92 ± 18.5% (t = 2.409, P < 0.05) in Child-Pugh A and Child-Pugh B + C cirrhotic patients, respectively. The percentage of late apoptotic marrow CD34+ cells was positively correlated with the total bilirubin and aspartate aminotransferase serum levels in patients with cirrhosis. CONCLUSION: The status of CD34+ marrow cells in cirrhotic patients may suggest that the ability of hematopoietic progenitor cells to transform into mature blood cells is impaired. |
| spellingShingle | Dang, S Wang, W Gao, N Wang, S Li, M Liu, L Sun, M Dong, T Apoptotic bone marrow CD34+ cells in cirrhotic patients. |
| title | Apoptotic bone marrow CD34+ cells in cirrhotic patients. |
| title_full | Apoptotic bone marrow CD34+ cells in cirrhotic patients. |
| title_fullStr | Apoptotic bone marrow CD34+ cells in cirrhotic patients. |
| title_full_unstemmed | Apoptotic bone marrow CD34+ cells in cirrhotic patients. |
| title_short | Apoptotic bone marrow CD34+ cells in cirrhotic patients. |
| title_sort | apoptotic bone marrow cd34 cells in cirrhotic patients |
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