Molecular radiotherapy using cleavable radioimmunoconjugates that target EGFR and γH2AX.
Many anticancer therapies, including ionizing radiation (IR), cause cytotoxicity through generation of DNA double-strand breaks (DSB). Delivery of therapeutic radionuclides to DNA DSB sites can amplify this DNA damage, for additional therapeutic gain. Herein, we report on two radiopharmaceuticals, r...
Những tác giả chính: | Cornelissen, B, Waller, A, Able, S, Vallis, K |
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Định dạng: | Journal article |
Ngôn ngữ: | English |
Được phát hành: |
American Association for Cancer Research
2013
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