Molecular radiotherapy using cleavable radioimmunoconjugates that target EGFR and γH2AX.
Many anticancer therapies, including ionizing radiation (IR), cause cytotoxicity through generation of DNA double-strand breaks (DSB). Delivery of therapeutic radionuclides to DNA DSB sites can amplify this DNA damage, for additional therapeutic gain. Herein, we report on two radiopharmaceuticals, r...
| Main Authors: | , , , |
|---|---|
| 格式: | Journal article |
| 语言: | English |
| 出版: |
American Association for Cancer Research
2013
|