UMOD-ulating CKD risk: untangling the relationship between urinary uromodulin, blood pressure, and kidney disease
A new Mendelian randomization study finds evidence that genetically predicted higher levels of urinary uromodulin are associated with lower kidney function and higher blood pressure. Bidirectional and multivariable Mendelian randomization suggests the association with higher blood pressure appears t...
| Main Authors: | , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Elsevier
2021
|
| Summary: | A new Mendelian randomization study finds evidence that genetically
predicted higher levels of urinary uromodulin are associated with
lower kidney function and higher blood pressure. Bidirectional and
multivariable Mendelian randomization suggests the association with
higher blood pressure appears to be partially through decreased
kidney function, but blood pressure does not appear to mediate the
association of uromodulin with low kidney function. We describe the
methods used for the bidirectional and multivariable Mendelian
randomization analyses and examine the validity of the assumptions
and implications of the results. |
|---|