A common prostate cancer risk variant 5' of microseminoprotein-beta (MSMB) is a strong predictor of circulating beta-microseminoprotein (MSP) levels in multiple populations.
BACKGROUND: β-Microseminoprotein (MSP) is one of the three most abundantly secreted proteins of the prostate and has been suggested as a biomarker for prostate cancer risk. A common variant, rs10993994, in the 5' region of the gene that encodes MSP (MSMB) has recently been identified as a risk...
| Glavni autori: | , , , , , , , , , |
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| Format: | Journal article |
| Jezik: | English |
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2010
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| _version_ | 1826297306246283264 |
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| author | Waters, K Stram, DO Le Marchand, L Klein, R Valtonen-André, C Peltola, M Kolonel, L Henderson, B Lilja, H Haiman, C |
| author_facet | Waters, K Stram, DO Le Marchand, L Klein, R Valtonen-André, C Peltola, M Kolonel, L Henderson, B Lilja, H Haiman, C |
| author_sort | Waters, K |
| collection | OXFORD |
| description | BACKGROUND: β-Microseminoprotein (MSP) is one of the three most abundantly secreted proteins of the prostate and has been suggested as a biomarker for prostate cancer risk. A common variant, rs10993994, in the 5' region of the gene that encodes MSP (MSMB) has recently been identified as a risk factor for prostate cancer. METHODS: We examined the association between rs10993994 genotype and MSP levels in a sample of 500 prostate cancer-free men from four racial/ethnic populations in the Multiethnic Cohort (European Americans, African Americans, Latinos, and Japanese Americans). Generalized linear models were used to estimate the association between rs10993994 genotype and MSP levels. RESULTS: We observed robust associations between rs10994994 genotype and MSP levels in each racial/ethnic population (all P < 10(-8)), with carriers of the C allele having lower geometric mean MSP levels (ng/mL; CC/CT/TT genotypes: European Americans, 28.8/20.9/10.0; African Americans, 29.0/21.9/10.9; Latinos, 29.2/17.1/8.3; and Japanese Americans, 25.8/16.4/6.7). We estimated the variant accounts for 30% to 50% of the variation in MSP levels in each population. We also observed significant differences in MSP levels between populations (P = 3.5 × 10(-6)), with MSP levels observed to be highest in African Americans and lowest in Japanese Americans. CONCLUSIONS: Rs10993994 genotype is strongly associated with plasma MSP levels in multiple racial/ethnic populations. IMPACT: This supports the hypothesis that rs10993994 may be the biologically functional allele. |
| first_indexed | 2024-03-07T04:29:34Z |
| format | Journal article |
| id | oxford-uuid:cdda3a3b-2b05-4c74-9233-9f66b0fc6b11 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:29:34Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:cdda3a3b-2b05-4c74-9233-9f66b0fc6b112022-03-27T07:31:32ZA common prostate cancer risk variant 5' of microseminoprotein-beta (MSMB) is a strong predictor of circulating beta-microseminoprotein (MSP) levels in multiple populations.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:cdda3a3b-2b05-4c74-9233-9f66b0fc6b11EnglishSymplectic Elements at Oxford2010Waters, KStram, DOLe Marchand, LKlein, RValtonen-André, CPeltola, MKolonel, LHenderson, BLilja, HHaiman, CBACKGROUND: β-Microseminoprotein (MSP) is one of the three most abundantly secreted proteins of the prostate and has been suggested as a biomarker for prostate cancer risk. A common variant, rs10993994, in the 5' region of the gene that encodes MSP (MSMB) has recently been identified as a risk factor for prostate cancer. METHODS: We examined the association between rs10993994 genotype and MSP levels in a sample of 500 prostate cancer-free men from four racial/ethnic populations in the Multiethnic Cohort (European Americans, African Americans, Latinos, and Japanese Americans). Generalized linear models were used to estimate the association between rs10993994 genotype and MSP levels. RESULTS: We observed robust associations between rs10994994 genotype and MSP levels in each racial/ethnic population (all P < 10(-8)), with carriers of the C allele having lower geometric mean MSP levels (ng/mL; CC/CT/TT genotypes: European Americans, 28.8/20.9/10.0; African Americans, 29.0/21.9/10.9; Latinos, 29.2/17.1/8.3; and Japanese Americans, 25.8/16.4/6.7). We estimated the variant accounts for 30% to 50% of the variation in MSP levels in each population. We also observed significant differences in MSP levels between populations (P = 3.5 × 10(-6)), with MSP levels observed to be highest in African Americans and lowest in Japanese Americans. CONCLUSIONS: Rs10993994 genotype is strongly associated with plasma MSP levels in multiple racial/ethnic populations. IMPACT: This supports the hypothesis that rs10993994 may be the biologically functional allele. |
| spellingShingle | Waters, K Stram, DO Le Marchand, L Klein, R Valtonen-André, C Peltola, M Kolonel, L Henderson, B Lilja, H Haiman, C A common prostate cancer risk variant 5' of microseminoprotein-beta (MSMB) is a strong predictor of circulating beta-microseminoprotein (MSP) levels in multiple populations. |
| title | A common prostate cancer risk variant 5' of microseminoprotein-beta (MSMB) is a strong predictor of circulating beta-microseminoprotein (MSP) levels in multiple populations. |
| title_full | A common prostate cancer risk variant 5' of microseminoprotein-beta (MSMB) is a strong predictor of circulating beta-microseminoprotein (MSP) levels in multiple populations. |
| title_fullStr | A common prostate cancer risk variant 5' of microseminoprotein-beta (MSMB) is a strong predictor of circulating beta-microseminoprotein (MSP) levels in multiple populations. |
| title_full_unstemmed | A common prostate cancer risk variant 5' of microseminoprotein-beta (MSMB) is a strong predictor of circulating beta-microseminoprotein (MSP) levels in multiple populations. |
| title_short | A common prostate cancer risk variant 5' of microseminoprotein-beta (MSMB) is a strong predictor of circulating beta-microseminoprotein (MSP) levels in multiple populations. |
| title_sort | common prostate cancer risk variant 5 of microseminoprotein beta msmb is a strong predictor of circulating beta microseminoprotein msp levels in multiple populations |
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