A dynamic folded Hairpin conformation is associated with α-Globin activation in Erythroid cells

A dynamic folded Hairpin conformation is associated with α-Globin activation in Erythroid cells

We investigate the three-dimensional (3D) conformations of the α-globin locus at the single-allele level in murine embryonic stem cells (ESCs) and erythroid cells, combining polymer physics models and high-resolution Capture-C data. Model predictions are validated against independent fluorescence in...

Full description

Bibliographic Details
Main Authors:	Chiariello, AM, Bianco, S, Oudelaar, AM, Esposito, A, Annunziatella, C, Fiorillo, L, Conte, M, Corrado, A, Prisco, A, Larke, MSC, Telenius, JM, Sciarretta, R, Musella, F, Buckle, VJ, Higgs, DR, Hughes, JR, Nicodemi, M
Format:	Journal article
Language:	English
Published:	Elsevier (Cell Press) 2020

Similar Items

A Polymer Physics Investigation of the Architecture of the Murine Orthologue of the 7q11.23 Human Locus
by: Andrea M. Chiariello, et al.
Published: (2017-10-01)

A revised model for promoter competition based on multi-way chromatin interactions at the α-globin locus
by: Oudelaar, A, et al.
Published: (2019)

Differential regulation of the α-globin locus by Krüppel-like factor 3 in erythroid and non-erythroid cells
by: Funnell, A, et al.
Published: (2014)

The role of histone deacetylases in repressing alpha-globin gene expression in non-erythroid cells.
by: Garrick, D, et al.
Published: (2003)

Polymer physics indicates chromatin folding variability across single-cells results from state degeneracy in phase separation
by: Mattia Conte, et al.
Published: (2020-07-01)

Single-allele chromatin interactions identify regulatory hubs in dynamic compartmentalized domains
by: Oudelaar, A, et al.
Published: (2018)

The three-dimensional regulatory landscapes of the globin genes
by: Oudelaar, A
Published: (2018)

A revised model for promoter competition based on multi-way chromatin interactions at the α-globin locus
by: A. Marieke Oudelaar, et al.
Published: (2019-11-01)

The α-globin super-enhancer acts in an orientation-dependent manner
by: Kassouf, MT, et al.
Published: (2025)

Identification of a conserved erythroid specific domain of histone acetylation across the a globin gene cluster.
by: Anguita, E, et al.
Published: (2001)

Identification of a conserved erythroid specific domain of histone acetylation across the alpha-globin gene cluster.
by: Anguita, E, et al.
Published: (2001)

The gene for theta-globin is transcribed in human fetal erythroid tissues.
by: Leung, S, et al.
Published: (1987)

The α-globin super-enhancer acts in an orientation-dependent manner
by: Mira T. Kassouf, et al.
Published: (2025-01-01)

Imbalanced globin chain synthesis determines erythroid cell pathology in thalassemic mice
by: Kanitta Srinoun, et al.
Published: (2009-09-01)

The relationship between genome structure and function
by: Oudelaar, AM, et al.
Published: (2020)

Genetic dissection of the α-globin super-enhancer in vivo
by: Hay, D, et al.
Published: (2016)

Spatial organization of the chicken beta-globin gene domain in erythroid cells of embryonic and adult lineages
by: Ulianov Sergey V, et al.
Published: (2012-09-01)

Spatial and temporal organisation of globin genes during erytroid differentiation.
by: Brown, J, et al.
Published: (2005)

Characterization of the transcriptome profiles related to globin gene switching during <it>in vitro </it>erythroid maturation
by: Li Biaoru, et al.
Published: (2012-04-01)

Eos negatively regulates human γ-globin gene transcription during erythroid differentiation.
by: Hai-Chuan Yu, et al.
Published: (2011-01-01)

CRISPR-Cas9 interrogation of a putative fetal globin repressor in human erythroid cells.
by: Jennifer E Chung, et al.
Published: (2019-01-01)

Reactivation of a developmentally silenced embryonic globin gene
by: King, AJ, et al.
Published: (2021)

Loop-extrusion and polymer phase-separation can co-exist at the single-molecule level to shape chromatin folding
by: Mattia Conte, et al.
Published: (2022-07-01)

DNA looping in the alpha-globin locus
by: Canals-Hamann, A, et al.
Published: (2007)

Understanding erythroid differentiation
by: Higgs, D, et al.
Published: (1993)

An early start of Coup-TFII promotes γ-globin gene expression in adult erythroid cells
by: Stefania Bottardi, et al.
Published: (2021-02-01)

Does Transcription of Remote alpha-Globin Regulatory Elements Affect Their Function?
by: Kowalczyk, MS, et al.
Published: (2009)

GEOGRAPHIC-DISTRIBUTION OF ALPHA-GLOBIN AND BETA-GLOBIN GENE-CLUSTER POLYMORPHISMS
by: Wainscoat, J, et al.
Published: (1989)

Enhancers predominantly regulate gene expression during differentiation via transcription initiation
by: Larke, MSC, et al.
Published: (2021)

The Role of Crowding Forces in Juxtaposing β-Globin Gene Domain Remote Regulatory Elements in Mouse Erythroid Cells.
by: Arkadiy K Golov, et al.
Published: (2015-01-01)

Expression profile of healthy erythroid progenitors
by: Merryweather-Clarke, A, et al.
Published: (2007)

P104: BASE EDITING REPAIRS THE HBE MUTATION RESTORING THE PRODUCTION OF NORMAL GLOBIN CHAINS IN SEVERE HBE/β-THALASSEMIA PATIENT HEMATOPOIETIC STEM AND ERYTHROID CELLS
by: M Badat, et al.
Published: (2022-01-01)

Induction of adult levels of β-globin in human erythroid cells that intrinsically express embryonic or fetal globin by transduction with KLF1 and BCL11A-XL
by: Kongtana Trakarnsanga, et al.
Published: (2014-11-01)

Coregulated human globin genes are frequently in spatial proximity when active
by: Brown, J, et al.
Published: (2006)

NRF2 mediates γ-globin gene regulation and fetal hemoglobin induction in human erythroid progenitors
by: Xingguo Zhu, et al.
Published: (2017-08-01)

Erythroid-specific expression of β-globin from Sleeping Beauty-transduced human hematopoietic progenitor cells.
by: Lucas M Sjeklocha, et al.
Published: (2011-01-01)

Reactivation of a developmentally silenced embryonic globin gene
by: Andrew J. King, et al.
Published: (2021-07-01)

Global gene expression analysis of human erythroid progenitors.
by: Merryweather-Clarke, A, et al.
Published: (2011)

Global gene expression analysis of human erythroid progenitors
by: Merryweather-Clarke, A, et al.
Published: (2011)

P104: Base editing repairs the HbE mutation restoring the production of normal globin chains in severe HbE/β-thalassemia patient hematopoietic stem and erythroid cells
by: Badat, M, et al.
Published: (2022)