Senktide, a selective neurokinin B-like agonist, elicits serotonin-mediated behaviour following intracisternal administration in the mouse.
Behavioural responses to tachykinins were observed following intracisternal administration in mice. The synthetic NK-3 agonists senktide and L-363,851 caused behaviour typically associated with serotonergic stimulation, including head twitches, reciprocal forepaw treading and hindlimb splaying. Neur...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
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1987
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| _version_ | 1826297315686612992 |
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| author | Stoessl, A Dourish, C Young, S Williams, B Iversen, S Iversen, L |
| author_facet | Stoessl, A Dourish, C Young, S Williams, B Iversen, S Iversen, L |
| author_sort | Stoessl, A |
| collection | OXFORD |
| description | Behavioural responses to tachykinins were observed following intracisternal administration in mice. The synthetic NK-3 agonists senktide and L-363,851 caused behaviour typically associated with serotonergic stimulation, including head twitches, reciprocal forepaw treading and hindlimb splaying. Neurokinin B produced some features of the serotonin (5-HT) syndrome, while substance P, neurokinin A and eledoisin failed to elicit any such behaviours. Senktide-induced head twitches were prevented by pretreatment with the 5-HT2 antagonists ketanserin and ritanserin, while forepaw treading was attenuated by the 5-HT1 antagonists (-)-pindolol and methysergide. These data suggest that NK-3 agonists interact with central 5-HT mechanisms. |
| first_indexed | 2024-03-07T04:29:43Z |
| format | Journal article |
| id | oxford-uuid:cde4fce9-9798-42a2-a973-54a4d87f02c4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:29:43Z |
| publishDate | 1987 |
| record_format | dspace |
| spelling | oxford-uuid:cde4fce9-9798-42a2-a973-54a4d87f02c42022-03-27T07:31:55ZSenktide, a selective neurokinin B-like agonist, elicits serotonin-mediated behaviour following intracisternal administration in the mouse.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:cde4fce9-9798-42a2-a973-54a4d87f02c4EnglishSymplectic Elements at Oxford1987Stoessl, ADourish, CYoung, SWilliams, BIversen, SIversen, LBehavioural responses to tachykinins were observed following intracisternal administration in mice. The synthetic NK-3 agonists senktide and L-363,851 caused behaviour typically associated with serotonergic stimulation, including head twitches, reciprocal forepaw treading and hindlimb splaying. Neurokinin B produced some features of the serotonin (5-HT) syndrome, while substance P, neurokinin A and eledoisin failed to elicit any such behaviours. Senktide-induced head twitches were prevented by pretreatment with the 5-HT2 antagonists ketanserin and ritanserin, while forepaw treading was attenuated by the 5-HT1 antagonists (-)-pindolol and methysergide. These data suggest that NK-3 agonists interact with central 5-HT mechanisms. |
| spellingShingle | Stoessl, A Dourish, C Young, S Williams, B Iversen, S Iversen, L Senktide, a selective neurokinin B-like agonist, elicits serotonin-mediated behaviour following intracisternal administration in the mouse. |
| title | Senktide, a selective neurokinin B-like agonist, elicits serotonin-mediated behaviour following intracisternal administration in the mouse. |
| title_full | Senktide, a selective neurokinin B-like agonist, elicits serotonin-mediated behaviour following intracisternal administration in the mouse. |
| title_fullStr | Senktide, a selective neurokinin B-like agonist, elicits serotonin-mediated behaviour following intracisternal administration in the mouse. |
| title_full_unstemmed | Senktide, a selective neurokinin B-like agonist, elicits serotonin-mediated behaviour following intracisternal administration in the mouse. |
| title_short | Senktide, a selective neurokinin B-like agonist, elicits serotonin-mediated behaviour following intracisternal administration in the mouse. |
| title_sort | senktide a selective neurokinin b like agonist elicits serotonin mediated behaviour following intracisternal administration in the mouse |
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