Peste des Petits Ruminants (PPR) virus serological surveillance in goats in Lao PDR: Issues for disease eradication in a low‐resource disease‐free setting
Peste des Petits ruminants (PPR) is an economically important transboundary viral disease of goats. This study aimed to determine a baseline of serological evidence for Peste des petits ruminants virus (PPRV) in Lao goats. A total of 1,072 serum samples were collected by convenience sampling across...
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| Format: | Journal article |
| Language: | English |
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Wiley
2018
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| _version_ | 1826297357733462016 |
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| author | Burns, RJL Douangngeun, B Theppangna, W Mukaka, M Wegner, MD Windsor, PA Blacksell, SD |
| author_facet | Burns, RJL Douangngeun, B Theppangna, W Mukaka, M Wegner, MD Windsor, PA Blacksell, SD |
| author_sort | Burns, RJL |
| collection | OXFORD |
| description | Peste des Petits ruminants (PPR) is an economically important transboundary viral disease of goats. This study aimed to determine a baseline of serological evidence for Peste des petits ruminants virus (PPRV) in Lao goats. A total of 1,072 serum samples were collected by convenience sampling across five provinces in Laos and tested for antibody response to PPRV using a commercially available competitive ELISA. Positive antibody responses were found in 2.2% (95% CI 1.4, 3.2) of the samples. True prevalence calculations indicated a total overall sample prevalence of 1.7% (95% CI 0.9, 2.8). The highest provincial seroprevalences were Xiangkhouang (3.5%, 95% CI 1.6, 6.9) and Xayaboury (2.9% (95% CI 1.3, 5.7). There was no association between antibody response and each of the following factors: location, breed, gender or age. Considering the apparent absence of disease manifestation of PPR in Laos, likely explanations for the antibody positivity could include cross reaction to other Morbilliviruses such as Measles or Canine Distemper, importation of pre-vaccinated goats, need for test cut-off re-evaluation to be region specific, or a subclinical and a less virulent circulating virus. This study highlights that the sampled Lao goat population is highly likely to be naïve to PPRV and therefore at risk of an outbreak, possibly by transboundary incursion of livestock from PPR endemic China. Further work is required in the testing of small ruminants in Laos that may eventually provide evidence for a status of freedom from disease, particularly in support of programs aimed at global PPR eradication. |
| first_indexed | 2024-03-07T04:30:22Z |
| format | Journal article |
| id | oxford-uuid:ce175ee1-71f4-402a-bc43-05ff3ab8b5c1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:30:22Z |
| publishDate | 2018 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:ce175ee1-71f4-402a-bc43-05ff3ab8b5c12022-03-27T07:33:24ZPeste des Petits Ruminants (PPR) virus serological surveillance in goats in Lao PDR: Issues for disease eradication in a low‐resource disease‐free settingJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ce175ee1-71f4-402a-bc43-05ff3ab8b5c1EnglishSymplectic Elements at OxfordWiley2018Burns, RJLDouangngeun, BTheppangna, WMukaka, MWegner, MDWindsor, PABlacksell, SDPeste des Petits ruminants (PPR) is an economically important transboundary viral disease of goats. This study aimed to determine a baseline of serological evidence for Peste des petits ruminants virus (PPRV) in Lao goats. A total of 1,072 serum samples were collected by convenience sampling across five provinces in Laos and tested for antibody response to PPRV using a commercially available competitive ELISA. Positive antibody responses were found in 2.2% (95% CI 1.4, 3.2) of the samples. True prevalence calculations indicated a total overall sample prevalence of 1.7% (95% CI 0.9, 2.8). The highest provincial seroprevalences were Xiangkhouang (3.5%, 95% CI 1.6, 6.9) and Xayaboury (2.9% (95% CI 1.3, 5.7). There was no association between antibody response and each of the following factors: location, breed, gender or age. Considering the apparent absence of disease manifestation of PPR in Laos, likely explanations for the antibody positivity could include cross reaction to other Morbilliviruses such as Measles or Canine Distemper, importation of pre-vaccinated goats, need for test cut-off re-evaluation to be region specific, or a subclinical and a less virulent circulating virus. This study highlights that the sampled Lao goat population is highly likely to be naïve to PPRV and therefore at risk of an outbreak, possibly by transboundary incursion of livestock from PPR endemic China. Further work is required in the testing of small ruminants in Laos that may eventually provide evidence for a status of freedom from disease, particularly in support of programs aimed at global PPR eradication. |
| spellingShingle | Burns, RJL Douangngeun, B Theppangna, W Mukaka, M Wegner, MD Windsor, PA Blacksell, SD Peste des Petits Ruminants (PPR) virus serological surveillance in goats in Lao PDR: Issues for disease eradication in a low‐resource disease‐free setting |
| title | Peste des Petits Ruminants (PPR) virus serological surveillance in goats in Lao PDR: Issues for disease eradication in a low‐resource disease‐free setting |
| title_full | Peste des Petits Ruminants (PPR) virus serological surveillance in goats in Lao PDR: Issues for disease eradication in a low‐resource disease‐free setting |
| title_fullStr | Peste des Petits Ruminants (PPR) virus serological surveillance in goats in Lao PDR: Issues for disease eradication in a low‐resource disease‐free setting |
| title_full_unstemmed | Peste des Petits Ruminants (PPR) virus serological surveillance in goats in Lao PDR: Issues for disease eradication in a low‐resource disease‐free setting |
| title_short | Peste des Petits Ruminants (PPR) virus serological surveillance in goats in Lao PDR: Issues for disease eradication in a low‐resource disease‐free setting |
| title_sort | peste des petits ruminants ppr virus serological surveillance in goats in lao pdr issues for disease eradication in a low resource disease free setting |
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