Decreased STARD10 expression is associated with defective insulin secretion in humans and mice.

Decreased STARD10 expression is associated with defective insulin secretion in humans and mice.

Εμφάνιση άλλων εκδόσεων (1)

Genetic variants near ARAP1 (CENTD2) and STARD10 influence type 2 diabetes (T2D) risk. The risk alleles impair glucose-induced insulin secretion and, paradoxically but characteristically, are associated with decreased proinsulin:insulin ratios, indicating improved proinsulin conversion. Neither the...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Carrat, G, Hu, M, Nguyen-Tu, M, Chabosseau, P, Gaulton, K, van de Bunt, M, Siddiq, A, Falchi, M, Thurner, M, Canouil, M, Pattou, F, Leclerc, I, Pullen, T, Cane, M, Prabhala, P, Greenwald, W, Schulte, A, Marchetti, P, Ibberson, M, MacDonald, P, Manning Fox, J, Gloyn, A, Froguel, P, Solimena, M, McCarthy, M, Rutter, G
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	Elsevier 2017

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