Decreased STARD10 expression is associated with defective insulin secretion in humans and mice.

Genetic variants near ARAP1 (CENTD2) and STARD10 influence type 2 diabetes (T2D) risk. The risk alleles impair glucose-induced insulin secretion and, paradoxically but characteristically, are associated with decreased proinsulin:insulin ratios, indicating improved proinsulin conversion. Neither the...

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Détails bibliographiques
Auteurs principaux:	Carrat, G, Hu, M, Nguyen-Tu, M, Chabosseau, P, Gaulton, K, van de Bunt, M, Siddiq, A, Falchi, M, Thurner, M, Canouil, M, Pattou, F, Leclerc, I, Pullen, T, Cane, M, Prabhala, P, Greenwald, W, Schulte, A, Marchetti, P, Ibberson, M, MacDonald, P, Manning Fox, J, Gloyn, A, Froguel, P, Solimena, M, McCarthy, M, Rutter, G
Format:	Journal article
Langue:	English
Publié:	Elsevier 2017

Decreased STARD10 expression is associated with defective insulin secretion in humans and mice.

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