Decreased STARD10 expression is associated with defective insulin secretion in humans and mice.

Decreased STARD10 expression is associated with defective insulin secretion in humans and mice.

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Genetic variants near ARAP1 (CENTD2) and STARD10 influence type 2 diabetes (T2D) risk. The risk alleles impair glucose-induced insulin secretion and, paradoxically but characteristically, are associated with decreased proinsulin:insulin ratios, indicating improved proinsulin conversion. Neither the...

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Những tác giả chính: Carrat, G, Hu, M, Nguyen-Tu, M, Chabosseau, P, Gaulton, K, van de Bunt, M, Siddiq, A, Falchi, M, Thurner, M, Canouil, M, Pattou, F, Leclerc, I, Pullen, T, Cane, M, Prabhala, P, Greenwald, W, Schulte, A, Marchetti, P, Ibberson, M, MacDonald, P, Manning Fox, J, Gloyn, A, Froguel, P, Solimena, M, McCarthy, M, Rutter, G
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: Elsevier 2017

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