Characterization of CCX282-B, an orally bioavailable antagonist of the CCR9 chemokine receptor, for treatment of inflammatory bowel disease.

Characterization of CCX282-B, an orally bioavailable antagonist of the CCR9 chemokine receptor, for treatment of inflammatory bowel disease.

The chemokine system represents a diverse group of G protein-coupled receptors responsible for orchestrating cell recruitment under both homeostatic and inflammatory conditions. Chemokine receptor 9 (CCR9) is a chemokine receptor known to be central for migration of immune cells into the intestine....

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Những tác giả chính: Walters, M, Wang, Y, Lai, N, Baumgart, T, Zhao, B, Dairaghi, D, Bekker, P, Ertl, L, Penfold, M, Jaen, J, Keshav, S, Wendt, E, Pennell, A, Ungashe, S, Wei, Z, Wright, J, Schall, T
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: 2010

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