Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype
Cdc2-like kinases (CLKs) represent a family of serine-threonine kinases involved in the regulation of splicing by phosphorylation of SR-proteins and other splicing factors. Although compounds acting against CLKs have been described, only a few show selectivity against dual-specificity tyrosine phosp...
Main Authors: | Walter, A, Chaikuad, A, Helmer, R, Loaëc, N, Preu, L, Ott, I, Knapp, S, Meijer, L, Kunick, C |
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Format: | Journal article |
Language: | English |
Published: |
Public Library of Science
2018
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