Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype

Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype

Cdc2-like kinases (CLKs) represent a family of serine-threonine kinases involved in the regulation of splicing by phosphorylation of SR-proteins and other splicing factors. Although compounds acting against CLKs have been described, only a few show selectivity against dual-specificity tyrosine phosp...

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Bibliographic Details
Main Authors:	Walter, A, Chaikuad, A, Helmer, R, Loaëc, N, Preu, L, Ott, I, Knapp, S, Meijer, L, Kunick, C
Format:	Journal article
Language:	English
Published:	Public Library of Science 2018

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