RNA interference mutant induction in vivo demonstrates the essential nature of trypanosome flagellar function during mammalian infection.

RNA interference mutant induction in vivo demonstrates the essential nature of trypanosome flagellar function during mammalian infection.

We demonstrate that trypanosomes compromised in flagellar function are rapidly cleared from infected mice. Analysis of the PFR2 bloodstream RNA interference mutant revealed that defective cell motility occurred prior to cytokinesis failure. This validation provides a paradigm for the flagellum as a...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Griffiths, S, Portman, N, Taylor, P, Gordon, S, Ginger, M, Gull, K
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	2007

Eitemau Tebyg

Flagellar motility is required for the viability of the bloodstream trypanosome.
gan: Broadhead, R, et al.
Cyhoeddwyd: (2006)

Trypanosome IFT mutants provide insight into the motor location for mobility of the flagella connector and flagellar membrane formation.
gan: Davidge, J, et al.
Cyhoeddwyd: (2006)

Flagellar and ciliary beating in trypanosome motility.
gan: Gadelha, C, et al.
Cyhoeddwyd: (2007)

Host-parasite interactions and trypanosome morphogenesis: a flagellar pocketful of goodies.
gan: Gull, K
Cyhoeddwyd: (2003)

Assembly and function of complex flagellar structures illustrated by the paraflagellar rod of trypanosomes.
gan: Bastin, P, et al.
Cyhoeddwyd: (1999)

Flagellar morphogenesis: protein targeting and assembly in the paraflagellar rod of trypanosomes.
gan: Bastin, P, et al.
Cyhoeddwyd: (1999)

Analysis of the trypanosome flagellar proteome using a combined electron transfer/collisionally activated dissociation strategy.
gan: Hart, SR, et al.
Cyhoeddwyd: (2009)

Membrane domains and flagellar pocket boundaries are influenced by the cytoskeleton in African trypanosomes.
gan: Gadelha, C, et al.
Cyhoeddwyd: (2009)

Functional complementation of RNA interference mutants in trypanosomes
gan: Bastin Philippe, et al.
Cyhoeddwyd: (2005-02-01)

Flagellar regeneration of the trypanosome Crithidia fasciculata involves post-translational modification of cytoplasmic alpha tubulin.
gan: Russell, D, et al.
Cyhoeddwyd: (1984)

Trypanin, a component of the flagellar Dynein regulatory complex, is essential in bloodstream form African trypanosomes.
gan: Katherine S Ralston, et al.
Cyhoeddwyd: (2006-09-01)

Three-dimensional cellular architecture of the flagellar pocket and associated cytoskeleton in trypanosomes revealed by electron microscope tomography.
gan: Lacomble, S, et al.
Cyhoeddwyd: (2009)

KHARON is an essential cytoskeletal protein involved in the trafficking of flagellar membrane proteins and cell division in African trypanosomes
gan: Sanchez, M, et al.
Cyhoeddwyd: (2016)

A high-order trans-membrane structural linkage is responsible for mitochondrial genome positioning and segregation by flagellar basal bodies in trypanosomes.
gan: Ogbadoyi, E, et al.
Cyhoeddwyd: (2003)

A high-order trans-membrane structural linkage is responsible for mitochondrial genome positioning and segregation by flagellar basal bodies in trypanosomes
gan: Ogbadoyi, E, et al.
Cyhoeddwyd: (2003)

Protein targeting and flagellum assembly dynamics revealed by paralysed mutant trypanosomes.
gan: Bastin, P, et al.
Cyhoeddwyd: (1999)

The Lipid Raft Proteome of African Trypanosomes Contains Many Flagellar Proteins
gan: Aabha I. Sharma, et al.
Cyhoeddwyd: (2017-08-01)

Protein diversity in discrete structures at the distal tip of the trypanosome flagellum
gan: Varga, V, et al.
Cyhoeddwyd: (2017)

Flagellar cAMP signaling controls trypanosome progression through host tissues
gan: Sebastian Shaw, et al.
Cyhoeddwyd: (2019-02-01)

The trypanosome flagellum.
gan: Vaughan, S, et al.
Cyhoeddwyd: (2003)

Flagellum ontogeny in trypanosomes studied via an inherited and regulated RNA interference system.
gan: Bastin, P, et al.
Cyhoeddwyd: (2000)

The Trypanosome Flagellar Pocket Collar and Its Ring Forming Protein—TbBILBO1
gan: Doranda Perdomo, et al.
Cyhoeddwyd: (2016-03-01)

A multi-adenylate cyclase regulator at the flagellar tip controls African trypanosome transmission
gan: Sabine Bachmaier, et al.
Cyhoeddwyd: (2022-09-01)

Cytokinesis in trypanosomes.
gan: Farr, H, et al.
Cyhoeddwyd: (2012)

Combining RNA interference mutants and comparative proteomics to identify protein components and dependences in a eukaryotic flagellum.
gan: Portman, N, et al.
Cyhoeddwyd: (2009)

Protein transport and flagellum assembly dynamics revealed by analysis of the paralysed trypanosome mutant snl-1.
gan: Bastin, P, et al.
Cyhoeddwyd: (1999)

Activation of endocytosis as an adaptation to the mammalian host by trypanosomes.
gan: Natesan, S, et al.
Cyhoeddwyd: (2007)

Evidence for loss of a partial flagellar glycolytic pathway during trypanosomatid evolution
gan: Brown, R, et al.
Cyhoeddwyd: (2014)

Chromosome-wide analysis of gene function by RNA interference in the african trypanosome.
gan: Subramaniam, C, et al.
Cyhoeddwyd: (2006)

Deconstructing the trypanosome cytoskeleton: from structures to functions via components and complexes.
gan: Portman, N
Cyhoeddwyd: (2011)

Sperm flagellar 2 (SPEF2) is essential for sperm flagellar assembly in humans
gan: Dong-Yan Li, et al.
Cyhoeddwyd: (2022-01-01)

Molecular architecture of the trypanosome cytoskeleton.
gan: Kohl, L, et al.
Cyhoeddwyd: (1998)

Basal body and flagellum mutants reveal a rotational constraint of the central pair microtubules in the axonemes of trypanosomes.
gan: Gadelha, C, et al.
Cyhoeddwyd: (2006)

Calmodulin is required for paraflagellar rod assembly and flagellum-cell body attachment in trypanosomes.
gan: Ginger, M, et al.
Cyhoeddwyd: (2013)

Cell biology of the trypanosome genome.
gan: Daniels, J, et al.
Cyhoeddwyd: (2010)

Variant surface glycoprotein RNA interference triggers a precytokinesis cell cycle arrest in African trypanosomes.
gan: Sheader, K, et al.
Cyhoeddwyd: (2005)

Evidence for loss of a partial flagellar glycolytic pathway during trypanosomatid evolution.
gan: Robert W B Brown, et al.
Cyhoeddwyd: (2014-01-01)

Species-Specific Adaptations of Trypanosome Morphology and Motility to the Mammalian Host.
gan: Joel L Bargul, et al.
Cyhoeddwyd: (2016-02-01)

Modulation of a cytoskeletal calpain-like protein induces major transitions in trypanosome morphology
gan: Hayes, P, et al.
Cyhoeddwyd: (2014)

The Roles of Individual Mammalian Argonautes in RNA Interference In Vivo
gan: Ruda, Vera M., et al.
Cyhoeddwyd: (2014)