RNA interference mutant induction in vivo demonstrates the essential nature of trypanosome flagellar function during mammalian infection.

RNA interference mutant induction in vivo demonstrates the essential nature of trypanosome flagellar function during mammalian infection.

We demonstrate that trypanosomes compromised in flagellar function are rapidly cleared from infected mice. Analysis of the PFR2 bloodstream RNA interference mutant revealed that defective cell motility occurred prior to cytokinesis failure. This validation provides a paradigm for the flagellum as a...

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Chi tiết về thư mục
Những tác giả chính:	Griffiths, S, Portman, N, Taylor, P, Gordon, S, Ginger, M, Gull, K
Định dạng:	Journal article
Ngôn ngữ:	English
Được phát hành:	2007

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