C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.

HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. Recent studies have defined posttranslational modification by prolyl hydroxylation as a key regulatory event that targets HIF-alpha subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylatio...

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Hlavní autoři: Epstein, A, Gleadle, J, McNeill, L, Hewitson, K, O'Rourke, J, Mole, D, Mukherji, M, Metzen, E, Wilson, M, Dhanda, A, Tian, Y, Masson, N, Hamilton, D, Jaakkola, P, Barstead, R, Hodgkin, J, Maxwell, P, Pugh, C, Schofield, C, Ratcliffe, P
Médium: Journal article
Jazyk:English
Vydáno: 2001

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