Crohn's disease, ulcerative colitis, and measles vaccine in an English population, 1979-1998.
STUDY OBJECTIVE:s: To study the hospitalised incidence of Crohn's disease (CD) and ulcerative colitis (UC) from 1979 to 1998; and to determine whether the introduction of the measles vaccination programme was associated with an increase in the young. DESIGN: Analysis of linked data on hospital...
| Κύριοι συγγραφείς: | , |
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| Μορφή: | Journal article |
| Γλώσσα: | English |
| Έκδοση: |
2003
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| _version_ | 1826297407821840384 |
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| author | Seagroatt, V Goldacre, M |
| author_facet | Seagroatt, V Goldacre, M |
| author_sort | Seagroatt, V |
| collection | OXFORD |
| description | STUDY OBJECTIVE:s: To study the hospitalised incidence of Crohn's disease (CD) and ulcerative colitis (UC) from 1979 to 1998; and to determine whether the introduction of the measles vaccination programme was associated with an increase in the young. DESIGN: Analysis of linked data on hospital admissions; a cohort analysis of the effect of the measles vaccination programme on the incidence of hospitalised CD and UC; and a comparison of these results with those from previous studies on the association between measles vaccine and CD or UC. SETTINGS: Southern England. SUBJECTS: People admitted to hospital with a main diagnosis of CD (1959 people) or UC (2018 people). MAIN RESULTS: Overall, the incidence of hospitalised CD showed no significant change over the 20 year period: the average change per year was 0.08% (95% confidence interval: -0.7% to 0.9%). The relative risk associated with the measles vaccination programme was not significant (0.91: 0.5 to 1.4). The estimate differed significantly from the relative risk of 3.0 obtained in the original study reporting an association, but agreed with the combined estimate from three subsequent studies (0.95: 0.6 to 1.5). The results for UC were similar. CONCLUSIONS: The incidence of hospitalised CD and UC remained stable over the 20 years, 1979 to 1998. Whatever caused the marked increases in CD and UC in the mid-20th century must itself have stabilised in this region. These results, together with those from other studies, provide strong evidence against measles vaccine causing CD or UC. |
| first_indexed | 2024-03-07T04:31:09Z |
| format | Journal article |
| id | oxford-uuid:ce5d6338-dcaa-43b5-a8b6-45d800b5e9a4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:31:09Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:ce5d6338-dcaa-43b5-a8b6-45d800b5e9a42022-03-27T07:35:05ZCrohn's disease, ulcerative colitis, and measles vaccine in an English population, 1979-1998.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ce5d6338-dcaa-43b5-a8b6-45d800b5e9a4EnglishSymplectic Elements at Oxford2003Seagroatt, VGoldacre, MSTUDY OBJECTIVE:s: To study the hospitalised incidence of Crohn's disease (CD) and ulcerative colitis (UC) from 1979 to 1998; and to determine whether the introduction of the measles vaccination programme was associated with an increase in the young. DESIGN: Analysis of linked data on hospital admissions; a cohort analysis of the effect of the measles vaccination programme on the incidence of hospitalised CD and UC; and a comparison of these results with those from previous studies on the association between measles vaccine and CD or UC. SETTINGS: Southern England. SUBJECTS: People admitted to hospital with a main diagnosis of CD (1959 people) or UC (2018 people). MAIN RESULTS: Overall, the incidence of hospitalised CD showed no significant change over the 20 year period: the average change per year was 0.08% (95% confidence interval: -0.7% to 0.9%). The relative risk associated with the measles vaccination programme was not significant (0.91: 0.5 to 1.4). The estimate differed significantly from the relative risk of 3.0 obtained in the original study reporting an association, but agreed with the combined estimate from three subsequent studies (0.95: 0.6 to 1.5). The results for UC were similar. CONCLUSIONS: The incidence of hospitalised CD and UC remained stable over the 20 years, 1979 to 1998. Whatever caused the marked increases in CD and UC in the mid-20th century must itself have stabilised in this region. These results, together with those from other studies, provide strong evidence against measles vaccine causing CD or UC. |
| spellingShingle | Seagroatt, V Goldacre, M Crohn's disease, ulcerative colitis, and measles vaccine in an English population, 1979-1998. |
| title | Crohn's disease, ulcerative colitis, and measles vaccine in an English population, 1979-1998. |
| title_full | Crohn's disease, ulcerative colitis, and measles vaccine in an English population, 1979-1998. |
| title_fullStr | Crohn's disease, ulcerative colitis, and measles vaccine in an English population, 1979-1998. |
| title_full_unstemmed | Crohn's disease, ulcerative colitis, and measles vaccine in an English population, 1979-1998. |
| title_short | Crohn's disease, ulcerative colitis, and measles vaccine in an English population, 1979-1998. |
| title_sort | crohn s disease ulcerative colitis and measles vaccine in an english population 1979 1998 |
| work_keys_str_mv | AT seagroattv crohnsdiseaseulcerativecolitisandmeaslesvaccineinanenglishpopulation19791998 AT goldacrem crohnsdiseaseulcerativecolitisandmeaslesvaccineinanenglishpopulation19791998 |