PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome.

PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome.

Previous work has shown that the protein kinase A (PKA)-regulated phosphodiesterase (PDE) 4D3 binds to A kinase-anchoring proteins (AKAPs). One such protein, AKAP9, localizes to the centrosome. In this paper, we investigate whether a PKA-PDE4D3-AKAP9 complex can generate spatial compartmentalization...

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Bibliographic Details
Main Authors: Terrin, A, Monterisi, S, Stangherlin, A, Zoccarato, A, Koschinski, A, Surdo, N, Mongillo, M, Sawa, A, Jordanides, N, Mountford, J, Zaccolo, M
Format: Journal article
Language:English
Published: 2012

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