Endogenous endothelin-1 signaling contributes to type I collagen and CCN2 overexpression in fibrotic fibroblasts.

Endogenous endothelin-1 signaling contributes to type I collagen and CCN2 overexpression in fibrotic fibroblasts.

Fibrosis is excessive scarring caused by the accumulation of extracellular matrix proteins and is a common end pathway in many chronic diseases. Endothelin-1 is a possible contributor to the persistent fibrotic phenotype of fibroblasts isolated from fibrotic lesions. In this report we used a specifi...

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Bibliographic Details
Main Authors:	Shi-Wen, X, Renzoni, E, Kennedy, L, Howat, S, Chen, Y, Pearson, J, Bou-Gharios, G, Dashwood, MR, du Bois, R, Black, C, Denton, C, Abraham, D, Leask, A
Format:	Journal article
Language:	English
Published:	2007

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