Endogenous endothelin-1 signaling contributes to type I collagen and CCN2 overexpression in fibrotic fibroblasts.

Endogenous endothelin-1 signaling contributes to type I collagen and CCN2 overexpression in fibrotic fibroblasts.

Fibrosis is excessive scarring caused by the accumulation of extracellular matrix proteins and is a common end pathway in many chronic diseases. Endothelin-1 is a possible contributor to the persistent fibrotic phenotype of fibroblasts isolated from fibrotic lesions. In this report we used a specifi...

Bibliografski detalji
Glavni autori:	Shi-Wen, X, Renzoni, E, Kennedy, L, Howat, S, Chen, Y, Pearson, J, Bou-Gharios, G, Dashwood, MR, du Bois, R, Black, C, Denton, C, Abraham, D, Leask, A
Format:	Journal article
Jezik:	English
Izdano:	2007

Slični predmeti

Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERK.
od: Xu, S, i dr.
Izdano: (2004)

Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts.
od: Shi-Wen, X, i dr.
Izdano: (2004)

Response of human lung fibroblast cells to stimulation by endothelin-1: Involvement of ras/MEK/ERK and PI3 kinase
od: Shiwen, X, i dr.
Izdano: (2003)

Bosentan alleviates the pro-fibrotic phenotype of lung scleroderma fibroblasts: Implications for treatment of scleroderma.
od: Leask, A, i dr.
Izdano: (2005)

Endothelin is a downstream mediator of profibrotic responses to transforming growth factor beta in human lung fibroblasts.
od: Shi-wen, X, i dr.
Izdano: (2007)

Fibroblast matrix gene expression and connective tissue remodeling: role of endothelin-1.
od: Shi-Wen, X, i dr.
Izdano: (2001)

Bosentan attenuates the profibrotic gene expression profile of lung fibroblasts in scleroderma
od: Shiwen, X, i dr.
Izdano: (2006)

CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts.
od: Shi-wen, X, i dr.
Izdano: (2006)

Gene expression profiling reveals novel TGFbeta targets in adult lung fibroblasts.
od: Renzoni, E, i dr.
Izdano: (2004)

Novel transforming growth factor beta transcriptional targets in adult lung fibroblasts indentified by microarray analysis
od: Renzoni, E, i dr.
Izdano: (2004)

CTGF Contributes to collagen type I expression in the bleomycin model of lung fibrosis and in human pulmonary fibroblasts by MAPK dependent transcriptional activation
od: Porticos, M, i dr.
Izdano: (2009)

Rac inhibition reverses the phenotype of fibrotic fibroblasts.
od: Shi-wen Xu, i dr.
Izdano: (2009-10-01)

Activation of a fibroblast-specific enhancer of the proalpha2(I) collagen gene in tight-skin mice.
od: Denton, C, i dr.
Izdano: (2001)

Gene expression profiling reveals novel TGFβ targets in adult lung fibroblasts
od: Pearson Jeremy D, i dr.
Izdano: (2004-11-01)

Yin/Yang expression of CCN family members: Transforming growth factor beta 1, via ALK5/FAK/MEK, induces CCN1 and CCN2, yet suppresses CCN3, expression in human dermal fibroblasts.
od: Alexander Peidl, i dr.
Izdano: (2019-01-01)

Matrix contraction by dermal fibroblasts requires transforming growth factor-beta/activin-linked kinase 5, heparan sulfate-containing proteoglycans, and MEK/ERK: insights into pathological scarring in chronic fibrotic disease.
od: Chen, Y, i dr.
Izdano: (2005)

Transcriptional regulation of the human alpha2(I) collagen gene (COL1A2), an informative model system to study fibrotic diseases.
od: Ramirez, F, i dr.
Izdano: (2006)

Post-traumatic osteoarthritis development is not modified by postnatal chondrocyte deletion of Ccn2
od: Craig M. Keenan, i dr.
Izdano: (2020-07-01)

Effect of nitric oxide on the differentiation of fibroblasts into myofibroblasts in the Peyronie's fibrotic plaque and in its rat model.
od: Vernet, D, i dr.
Izdano: (2002)

Activation of key profibrotic mechanisms in transgenic fibroblasts expressing kinase-deficient type II Transforming growth factor-{beta} receptor (T{beta}RII{delta}k).
od: Denton, C, i dr.
Izdano: (2005)

CCN1 expression by fibroblasts is required for bleomycin-induced skin fibrosis
od: Katherine Quesnel, i dr.
Izdano: (2019-08-01)

A search for polymorphism(s) in the far upstream region of the human PRO alpha 2(I) collagen gene.
od: Fonseca, C, i dr.
Izdano: (2000)

The matricellular protein CCN5 inhibits fibrotic deformation of retinal pigment epithelium.
od: Aeri Yoon, i dr.
Izdano: (2018-01-01)

A novel TGF-beta response element located in the human collagen type I alpha 2 far upstream enhancer is SMAD-independent
od: Ponticos, M, i dr.
Izdano: (2006)

Mechanical tension increases CCN2/CTGF expression and proliferation in gingival fibroblasts via a TGFβ-dependent mechanism.
od: Fen Guo, i dr.
Izdano: (2011-01-01)

Multiple enhancer regions govern the transcription of CCN2 during embryonic development
od: Frost, S, i dr.
Izdano: (2017)

Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen.
od: Ponticos, M, i dr.
Izdano: (2009)

Gene expression profiling of fibroblasts in response to applied bio-mechanical force
od: Eastwood, M, i dr.
Izdano: (2007)

Organ-specific collagen expression: implications for renal disease.
od: Alexakis, C, i dr.
Izdano: (2006)

Regulation of collagen type I in vascular smooth muscle cells by competition between Nkx2.5 and deltaEF1/ZEB1.
od: Ponticos, M, i dr.
Izdano: (2004)

Implication of the satellite cell in dystrophic muscle fibrosis: a self-perpetuating mechanism of collagen overproduction.
od: Alexakis, C, i dr.
Izdano: (2007)

Blocking endothelin: breaking new ground
od: R. M. du Bois
Izdano: (2007-08-01)

The TSP-1 domain of the matricellular protein CCN5 is essential for its nuclear localization and anti-fibrotic function.
od: Min Ho Song, i dr.
Izdano: (2022-01-01)

The extracellular matrix protein type I collagen and fibronectin are regulated by β-arrestin-1/endothelin axis in human ovarian fibroblasts
od: Ilenia Masi, i dr.
Izdano: (2025-02-01)

Adiponectin is an endogenous anti-fibrotic mediator and therapeutic target
od: Roberta G. Marangoni, i dr.
Izdano: (2017-06-01)

Use of Patterned Collagen Coated Slides to Study Normal and Scleroderma Lung Fibroblast Migration
od: Bahja Ahmed Abdi, i dr.
Izdano: (2017-06-01)

Col1a2 enhancer regulates collagen activity during development and in adult tissue repair.
od: Ponticos, M, i dr.
Izdano: (2004)

IL-1β-mediated adaptive reprogramming of endogenous human cardiac fibroblasts to cells with immune features during fibrotic remodeling
od: Jamila H. Siamwala, i dr.
Izdano: (2023-11-01)

Transcriptional regulation of the human alpha2(I) collagen gene
od: Antoniv, T, i dr.
Izdano: (2006)

Secreted Factors from Keloid Keratinocytes Modulate Collagen Deposition by Fibroblasts from Normal and Fibrotic Tissue: A Pilot Study
od: Mansour A. Alghamdi, i dr.
Izdano: (2020-07-01)