Norfluoxetine inhibits TREK-2 K2P channels by multiple mechanisms including state-independent effects on the selectivity filter gate

Norfluoxetine inhibits TREK-2 K2P channels by multiple mechanisms including state-independent effects on the selectivity filter gate

The TREK subfamily of two-pore domain K+ (K2P) channels are inhibited by fluoxetine and its metabolite, norfluoxetine (NFx). Although not the principal targets of this antidepressant, TREK channel inhibition by NFx has provided important insights into the conformational changes associated with chann...

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Dades bibliogràfiques
Autors principals:	Proks, P, Schewe, M, Conrad, LJ, Rao, S, Rathje, K, Rödström, KEJ, Carpenter, EP, Baukrowitz, T, Tucker, SJ
Format:	Journal article
Idioma:	English
Publicat:	Rockefeller University Press 2021

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