Common variation in the CD36 (fatty acid translocase) gene is associated with left-ventricular mass.
AIMS: Genetic variation in the fatty acid translocase (CD36) gene has been shown in animal models to affect several risk factors for the development of left-ventricular hypertrophy, but this phenotype has not, thus far, been investigated in humans. We examined the relationship between common genetic...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
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2011
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| _version_ | 1797095738451165184 |
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| author | Hall, D Mayosi, B Rahman, T Avery, P Watkins, H Keavney, B |
| author_facet | Hall, D Mayosi, B Rahman, T Avery, P Watkins, H Keavney, B |
| author_sort | Hall, D |
| collection | OXFORD |
| description | AIMS: Genetic variation in the fatty acid translocase (CD36) gene has been shown in animal models to affect several risk factors for the development of left-ventricular hypertrophy, but this phenotype has not, thus far, been investigated in humans. We examined the relationship between common genetic polymorphisms in the CD36 gene and left-ventricular mass. METHODS AND RESULTS: We studied a cohort of 255 families comprising 1425 individuals ascertained via a hypertensive proband. Seven single-nucleotide polymorphisms which together tagged common genetic variation in the CD36 gene were genotyped using a SEQUENOM MALDI-TOF instrument. There was evidence of association between the rs1761663 polymorphism in intron 1 of the CD36 gene and left-ventricular mass determined either by echocardiography (P=0.003, N=780) or electrocardiography (P=0.001, N=814). There was also association between rs1761663 genotype and body mass index (P<0.001, N=1354). Genotype was associated with between 2 and 8% differences in these phenotypes per allele. After adjustment for the effect of body mass index, there remained significant associations between genotype and left ventricular mass measured either by echo (P=0.017) or ECG (P=0.007). CONCLUSIONS: Genotype at the rs1761663 polymorphism has independent effects both on body mass index and left-ventricular mass. Genes with such pleiotropic effects may be particularly attractive therapeutic targets for interventions to modify multiple risk factors for cardiovascular events. |
| first_indexed | 2024-03-07T04:32:11Z |
| format | Journal article |
| id | oxford-uuid:ceb0b2c3-0f56-4580-a09f-35ec0a075ddc |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:32:11Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:ceb0b2c3-0f56-4580-a09f-35ec0a075ddc2022-03-27T07:37:30ZCommon variation in the CD36 (fatty acid translocase) gene is associated with left-ventricular mass.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ceb0b2c3-0f56-4580-a09f-35ec0a075ddcEnglishSymplectic Elements at Oxford2011Hall, DMayosi, BRahman, TAvery, PWatkins, HKeavney, BAIMS: Genetic variation in the fatty acid translocase (CD36) gene has been shown in animal models to affect several risk factors for the development of left-ventricular hypertrophy, but this phenotype has not, thus far, been investigated in humans. We examined the relationship between common genetic polymorphisms in the CD36 gene and left-ventricular mass. METHODS AND RESULTS: We studied a cohort of 255 families comprising 1425 individuals ascertained via a hypertensive proband. Seven single-nucleotide polymorphisms which together tagged common genetic variation in the CD36 gene were genotyped using a SEQUENOM MALDI-TOF instrument. There was evidence of association between the rs1761663 polymorphism in intron 1 of the CD36 gene and left-ventricular mass determined either by echocardiography (P=0.003, N=780) or electrocardiography (P=0.001, N=814). There was also association between rs1761663 genotype and body mass index (P<0.001, N=1354). Genotype was associated with between 2 and 8% differences in these phenotypes per allele. After adjustment for the effect of body mass index, there remained significant associations between genotype and left ventricular mass measured either by echo (P=0.017) or ECG (P=0.007). CONCLUSIONS: Genotype at the rs1761663 polymorphism has independent effects both on body mass index and left-ventricular mass. Genes with such pleiotropic effects may be particularly attractive therapeutic targets for interventions to modify multiple risk factors for cardiovascular events. |
| spellingShingle | Hall, D Mayosi, B Rahman, T Avery, P Watkins, H Keavney, B Common variation in the CD36 (fatty acid translocase) gene is associated with left-ventricular mass. |
| title | Common variation in the CD36 (fatty acid translocase) gene is associated with left-ventricular mass. |
| title_full | Common variation in the CD36 (fatty acid translocase) gene is associated with left-ventricular mass. |
| title_fullStr | Common variation in the CD36 (fatty acid translocase) gene is associated with left-ventricular mass. |
| title_full_unstemmed | Common variation in the CD36 (fatty acid translocase) gene is associated with left-ventricular mass. |
| title_short | Common variation in the CD36 (fatty acid translocase) gene is associated with left-ventricular mass. |
| title_sort | common variation in the cd36 fatty acid translocase gene is associated with left ventricular mass |
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